Morphology of subcutaneous tumors in xenografts of MDA MB231 in presence or absence of PICP. Histology of subcutaneous tumors generated by MDA MB231 and injected weekly with either vehicle or with PICP. Slices of criopreserved tumors collected after 14, 21 days and of paraffin embedded tumors at 48 days were stained with hematoxylin and eosin. Micrographs from individual tumors shown here are representative of the findings in 3 to 8 tumors for each time point. Note the presence of large vessels containing blood cells in the PICP-treated tumors, not observed in the control tumors, at 21 days and the diffuse presence of vessels at 48 days in C3 treated tumors. Enlargement is: first row 50×, second and third row 100×.