Figure 3From: Role of oxidative stress and intracellular glutathione in the sensitivity to apoptosis induced by proteasome inhibitor in thyroid cancer cells Effects of bortezomib on the synthesis of glutathione. Cells were treated with 50 nM bortezomib for the indicated time, intracellular GCL (A) and GS (B) activity were measured. In the parallel experiments, GCLC (C) and GS (D) mRNA levels were investigated using real time PCR. *, P< 0.05; ** P < 0.001 vs 0 hour treatment.Back to article page