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Table 2 Details on genes regulated by CtBP1 associated to melanoma development Genes with TCF/LEF binding sites in their promoter were analyzed.

From: Loss of full length CtBP1 expression enhances the invasive potential of human melanoma

Gene symbol

Gene name

TCF/LEF site

GDS1989 [xfold ind., Nevus set as 1] [11]

CtBP1 clones versus mock

Hoek et al.[12]

x fold ind.

P <

   

MIS

RGP

LN met

 

prol.

inv.

  

AP1S1

adaptor-related protein complex 1. sigma 1 subunit

+

2.02

2.99

5.23

0.77

0.99

1.10

1.11

ns

ATP1B1

ATPase. Na+/K+ transporting. beta 1 polypeptide

+

3.11

3.89

2.63

0.77

1.01

2.05

2.03

ns

CLDN11

claudin 11 (oligodendrocyte transmembrane protein)

+

1.06

5.15

2.30

0.67

1.97

128.6

65.38

0.003

COL1A2

collagen type I alpha 2

+

1.01

2.90

2.00

0.38

6.25

34.62

5.54

0.005

ENC1

ectodermal-neural cortex (with BTB-like domain)

+

2.58

13.19

14.38

0.68

0.69

2.66

3.88

0.003

ENPP2

ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)

+

0.86

1.36

2.31

0.66

1.40

4.43

3.17

0.047

FAT

FAT tumor suppressor homolog 1 (Drosophila)

+

1.29

2.65

3.29

0.52

0.85

1.66

1.95

0.004

FSCN1

fascin homolog 1. actin-bundling protein (Strongylocentrotus purpuratus)

+

2.07

4.36

3.21

0.79

0.75

2.77

3.67

0.0002

FUS

fusion (involved in t(12;16) in malignant liposarcoma)

+

1.70

2.59

3.29

0.82

1.31

0.94

0.71

0.039

MLL5

myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog. Drosophila)

+

1.77

3.43

3.91

1.32

1.22

1.03

0.85

ns

SLC26A2

solute carrier family 26 (sulfate transporter). member 2

+

1.86

4.8

3.11

0.41

1.20

1.87

1.56

ns

THBS1

thrombospondin 1

+

1.28

5.91

3.61

1.2

0.27

13.59

49.87

9.46E-06

TMED4

transmembrane emp24 protein transport domain containing 4

+

0.81

1.75

1.99

0.74

0.91

1.73

1.89

0.002

VCAN

versican

+

0.88

3.02

4.53

0.42

0.73

15.43

21.24

0.0001

  1. Using the micro array data GDS1989 [11] upregulation of these genes during melanoma development and progression is shown in columns 4 to 6. The regulation of these genes by CtBP1 was quantified in CtBP1 expressing cell clones by real time-PCR (column 7). For analysis of the proliferative and invasive phenotype the data of Hoek et al. [12] were used (column 8, 9). P-value < 0.05 was printed in bold. Abbreviations: MIS, melanoma-in-situ; RGP, radial growth phase; LN met, lymph node metastasis; prol., proliferative phenotype; inv., invasive phenotype.
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BMC Cancer

ISSN: 1471-2407

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