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Table 2 Details on genes regulated by CtBP1 associated to melanoma development Genes with TCF/LEF binding sites in their promoter were analyzed.

From: Loss of full length CtBP1 expression enhances the invasive potential of human melanoma

Gene symbol Gene name TCF/LEF site GDS1989 [xfold ind., Nevus set as 1] [11] CtBP1 clones versus mock Hoek et al.[12] x fold ind. P <
    MIS RGP LN met   prol. inv.   
AP1S1 adaptor-related protein complex 1. sigma 1 subunit + 2.02 2.99 5.23 0.77 0.99 1.10 1.11 ns
ATP1B1 ATPase. Na+/K+ transporting. beta 1 polypeptide + 3.11 3.89 2.63 0.77 1.01 2.05 2.03 ns
CLDN11 claudin 11 (oligodendrocyte transmembrane protein) + 1.06 5.15 2.30 0.67 1.97 128.6 65.38 0.003
COL1A2 collagen type I alpha 2 + 1.01 2.90 2.00 0.38 6.25 34.62 5.54 0.005
ENC1 ectodermal-neural cortex (with BTB-like domain) + 2.58 13.19 14.38 0.68 0.69 2.66 3.88 0.003
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) + 0.86 1.36 2.31 0.66 1.40 4.43 3.17 0.047
FAT FAT tumor suppressor homolog 1 (Drosophila) + 1.29 2.65 3.29 0.52 0.85 1.66 1.95 0.004
FSCN1 fascin homolog 1. actin-bundling protein (Strongylocentrotus purpuratus) + 2.07 4.36 3.21 0.79 0.75 2.77 3.67 0.0002
FUS fusion (involved in t(12;16) in malignant liposarcoma) + 1.70 2.59 3.29 0.82 1.31 0.94 0.71 0.039
MLL5 myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog. Drosophila) + 1.77 3.43 3.91 1.32 1.22 1.03 0.85 ns
SLC26A2 solute carrier family 26 (sulfate transporter). member 2 + 1.86 4.8 3.11 0.41 1.20 1.87 1.56 ns
THBS1 thrombospondin 1 + 1.28 5.91 3.61 1.2 0.27 13.59 49.87 9.46E-06
TMED4 transmembrane emp24 protein transport domain containing 4 + 0.81 1.75 1.99 0.74 0.91 1.73 1.89 0.002
VCAN versican + 0.88 3.02 4.53 0.42 0.73 15.43 21.24 0.0001
  1. Using the micro array data GDS1989 [11] upregulation of these genes during melanoma development and progression is shown in columns 4 to 6. The regulation of these genes by CtBP1 was quantified in CtBP1 expressing cell clones by real time-PCR (column 7). For analysis of the proliferative and invasive phenotype the data of Hoek et al. [12] were used (column 8, 9). P-value < 0.05 was printed in bold. Abbreviations: MIS, melanoma-in-situ; RGP, radial growth phase; LN met, lymph node metastasis; prol., proliferative phenotype; inv., invasive phenotype.