Frequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene 'FAT' in human astrocytic tumors

Table 4 Summary of LOH analysis of FATgene locus in astrocytic tumors (20 grade II and 20 grade IV) by RFLP using SNP markers.

Summary of LOH detected with each SNP markers
SNP-Markers		rs22 76930	rs37 33414	rs45 5600	rs21 3090	rs45 0320	rs76 63350	rs11 93110	rs12 98865
Informative samples	Grade II	0/20 (0%)	15/20 (75%)	7/20 (35%)	9/20 (45%)	12/20 (60%)	7/20 (35%)	2/20 (10%)	0/20 (0%)
	Grade IV	0/20 (0%)	8/20 (40%)	6/20 (30%)	6/20 (30%)	10/20 (50%)	0/20 (0%)	2/20 (10%)	1/20 (5%)
LOH per informative samples	Grade II	0/20 (0%)	2/15 (13.33%)	2/7 (28.57%)	3/9 (33.33%)	4/12 (33.33%)	0/7 (0%)	0/2 (0%)	0/0 (0%)
	Grade IV	0/20 (0%)	3/8 (37.5%)	2/6 (33.33%)	3/6 (50%)	5/10 (50%)	0/0 (0%)	1/2 (50%)	1/1 (100%)
Total LOH (Grade II & IV)		0/20 (0%)	5/23 21.73%	4/13 30.73%	6/15 40%	9/22 40.90%	0/7 (0%)	1/4 25%	1/1 100%
LOH per informative samples
Samples		Grade II (N = 20)		Grade IV (N = 20)			Grade II&IV (N = 40)
Overall SNP LOH per informative samples		8/19* (42.10%)		11/19* (57.89%)			19/38 (50%)

And SNP LOH detected per informative samples (Grade II and IV) with all SNP markers.
* In both grade II and grade IV one sample each were uninformative with all the SNP markers used.

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