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Table 4 HPV detection and typing of 15 HNSCC and 3 RRP patients.

From: Sensitive HPV detection in oropharyngeal cancers

    HPV detection method
Patient Age Diagnosis PGMY 09/11 Linear Array GP5+/GP6+ nest
1 52 SCC - - HPV 6
2 46 SCC - - HPV 6
3 49 SCC - - HPV 16, mixed
4 58 RRP - - -
5 68 SCC - HPV 16 HPV 16
6 31 RRP HPV 11 HPV 11 HPV 11
7 61 SCC - - -
8 68 SCC - - -
9 54 SCC - HPV 16 HPV 6
10 64 SCC - - HPV 6
11 72 SCC - - HPV 16
12 73 SCC - HPV 11 HPV 6
13 87 RRP - - -
14 69 SCC - - -
15 74 SCC - - -
16 50 SCC - - HPV 40
17 78 SCC - - mixed types
18 74 SCC - - -
HPV +ve HNSCC detection 0/15 3/15 10/15
  1. PCR detection, using the PGMY09/11 primer set was unable to detect the presence of HPV in any of the head and neck squamous cell carcinoma (SCC) samples (0/15). Improved detection was achieved using the Linear Array assay (3/15) and following a nested PCR of the PGMY reaction with the GP5+/GP6+ primer set (10/15). HPV was only detected in 1/3 of recurrent respiratory papillomatosis (RRP) samples, irrespective of the method used. Samples were scored as positive if HPV was detected using one or more of the methods employed.