Table 3 Associations according to age stratification
From: Nuclear receptor coregulator SNP discovery and impact on breast cancer risk
SNP | Genotypes | Cases | Controls | OR | 95% CI | P |
|---|---|---|---|---|---|---|
Cases and Controls ≥50 | ||||||
SRC-1 | CC (%) | 306 (93.9) | 747 (94.9) | 1 | Â | Â |
rs1804645 | CT (%) | 20 (6.1) | 40 (5.1) | 1.22 | 0.70-2.12 | 0.479 |
P1272S | TT (%) | 0 (0.0) | 0 (0.0) | - | - | - |
| Â | Â | [CT + TT]<-> [CC] | 1.22 | 0.70-2.12 | 0.479 | |
SRC-3 | CC (%) | 299 (92.8) | 691 (89.0) | 1 | Â | Â |
rs6094752 | CT (%) | 20 (6.2) | 80 (10.4) | 0.58 | 0.35-0.96 | 0.033 |
C218R | TT (%) | 3 (1.0) | 5 (0.6) | 1.39 | 0.33-5.84 | 0.654 |
| Â | Â | [CT + TT]<-> [CC] | 0.62 | 0.39-1.01 | 0.053 | |
SRC-3 | GG (%) | 253 (78.1) | 623 (79.4) | 1 | Â | Â |
rs2230782 | GC (%) | 68 (21.0) | 150 (19.1) | 1.12 | 0.81-1.54 | 0.502 |
Q586H | CC (%) | 3 (0.9) | 12 (1.5) | 0.62 | 0.17-2.20 | 0.451 |
| Â | Â | [CC]<-> [GG + GC] | 0.60 | 0.16-2.14 | 0.429 | |
SRC-3 | AA (%) | 270 (83.6) | 653 (82.5) | 1 | Â | Â |
rs2076546 | AG (%) | 52 (16.1) | 126 (15.9) | 0.99 | 0.70-1.42 | 0.991 |
T960T | GG (%) | 1 (0.3) | 12 (1.6) | 0.20 | 0.02-1.56 | 0.088 |
| Â | Â | [AG + GG]<-> [AA] | 0.93 | 0.66-1.31 | 0.676 | |
SMRT | GG (%) | 222 (69.4) | 517 (67.0) | 1 | Â | Â |
rs2229840 | AG (%) | 89 (27.8) | 220 (28.5) | 0.94 | 0.70-1.26 | 0.689 |
A1706T | AA (%) | 9 (2.8) | 35 (4.5) | 0.59 | 0.28-1.27 | 0.175 |
| Â | Â | [AG + GG]<-> [AA] | 0.89 | 0.68-1.18 | 0.439 | |
Cases and Controls < 50 | ||||||
SRC-1 | CC (%) | 682 (94.4) | 685 (94.9) | 1 | Â | Â |
rs1804645 | CT (%) | 38 (5.3) | 37 (5.1) | 1.03 | 0.65-1.64 | 0.896 |
P1272S | TT (%) | 2 (0.3) | 0 (0.0) | - | - | - |
| Â | Â | [CT + TT]<-> [CC] | 1.08 | 0.69-1.72 | 0.725 | |
SRC-3 | CC (%) | 633 (88.6) | 639 (89.4) | 1 | Â | Â |
rs6094752 | CT (%) | 77 (10.8) | 72 (10.1) | 1.08 | 0.77-1.52 | 0.658 |
C218R | TT (%) | 4 (0.6) | 4 (0.6) | 1.01 | 0.25-4.05 | 0.989 |
| Â | Â | [CT + TT]<-> [CC] | 1.08 | 0.77-1.50 | 0.665 | |
SRC-3 | GG (%) | 592 (82.2) | 584 (81.3) | 1 | Â | Â |
rs2230782 | GC (%) | 122 (16.9) | 122 (17.0) | 0.98 | 0.75-1.30 | 0.923 |
Q586H | CC (%) | 6 (0.9) | 12 (1.7) | 0.49 | 0.18-1.32 | 0.152 |
| Â | Â | [CC]<-> [GG + GC] | 0.49 | 0.18-1.32 | 0.153 | |
SRC-3 | AA (%) | 592 (82.1) | 587 (81.7) | 1 | Â | Â |
rs2076546 | AG (%) | 123 (17.1) | 123 (17.1) | 0.99 | 0.75-1.30 | 0.952 |
T960T | GG (%) | 6 (0.8) | 8 (1.2) | 0.74 | 0.26-2.16 | 0.584 |
| Â | Â | [AG + GG]<-> [AA] | 0.98 | 0.75-1.28 | 0.862 | |
SMRT | GG (%) | 470 (66.9) | 487 (68.4) | 1 | Â | Â |
rs2229840 | AG (%) | 202 (28.8) | 203 (28.5) | 1.03 | 0.82-1.30 | 0.796 |
A1706T | AA (%) | 30 (4.3) | 22 (3.1) | 1.41 | 0.80-2.48 | 0.228 |
| Â | Â | [AG + GG]<-> [AA] | 1.07 | 0.85-1.33 | 0.561 | |