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Table 3 Correlations between HIF-1α mRNA and other molecular markers as well as prognostic significance.

From: Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery

  HIF-1α COX-2 MMP7 PDGFRA MMP9 MYC VEGF
Correlation (P) 0.000 < 0.001 < 0.001 < 0.001 < 0.001 0.016 0.183
Coefficient (r) 1.000 0.708 0.593 0.493 0.384 0.230 0.128
OS (P) 0.012 0.004 0.010 0.010 NS NS NS
DFS (P) 0.004 0.010 NS 0.038 NS NS NS
  1. Detailed legends: The P values for correlation were determined by spearman's coefficience. The P values for OS and DFS were calculated using multivariate Cox proportional hazards analysis. All factors were presented in different multivariable analysis respectively and variables were adopted for their prognostic significance by univariate analysis. NS means not significant (P > 0.05).