Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study

Table 5 Interactions between nonsteroidal anti-inflammatory drug (NSAID) use and MDR1, COX-2 and BCRP polymorphisms.

Polymorphism	N_case/N_sub-cohort		IRR^a (95% CI)				IRR^b (95% CI)				p-value^c
	NSAID^d		NSAID^d				NSAID^d
	NO	YES	NO		YES		NO		YES
MDR1 C3435T
CC	41/79	32/39	1.00	-	2.21	(1.17-4.17)	1.00	-	2.34	(1.22-4.48)	0.001
CT and TT	204/449	82/198	0.92	(0.60-1.41)	0.83	(0.52-1.33)	0.99	(0.63-1.54)	0.86	(0.53-1.39)
MDR1 G-rs 3789243-A
GG	54/160	27/64	1.00	-	1.35	(0.77-2.35)	1.00	-	1.31	(0.74-2.32)	0.26
GA and AA	191/368	87/173	1.65	(1.15-2.38)	1.65	(1.09-2.49)	1.66	(1.15-2.41)	1.61	(1.06-2.46)
COX-2 G-765C
GG	180/397	87/169	1.00	-	1.22	(0.89-1.69)	1.00	-	1.20	(0.86-1.67)	0.06
CG and CC	65/131	27/68	1.22	(0.86-1.75)	0.93	(0.57-1.51)	1.23	(0.85-1.78)	0.90	(0.54-1.48)
COX-2 A-1195G
AA	156/329	74/153	1.00	-	1.05	(0.75-1.48)	1.00	-	0.99	(0.69-1.41)	0.46
AG and GG	89/199	40/84	0.91	(0.66-1.27)	1.04	(0.67-1.60)	0.88	(0.63-1.23)	1.04	(0.67-1.61)
COX-2 T8473C
TT	94/222	53/93	1.00	-	1.42	(0.92-2.18)	1.00	-	1.38	(0.89-2.14)	0.04
CT and CC	151/306	61/144	1.23	(0.89-1.70)	1.09	(0.73-1.62)	1.22	(0.87-1.69)	1.05	(0.70-1.58)
BCRP C421A
CC	199/414	97/178	1.00	-	1.20	(0.88-1.63)	1.00	-	1.18	(0.85-1.62)	0.09
CA and AA	46/114	17/59	0.86	(0.58-1.27)	0.62	(0.35-1.10)	0.86	(0.57-1.29)	0.60	(0.33-1.08)

^aCrude (adjusted for age and sex).
^bAdjusted for status of HRT (women only), smoking status, alcohol, dietary fibre, red meat and BMI.
^cp-value for interaction for the fully adjusted risk estimates.
^dStudy subjects were classified according to use of "any NSAID" (≥ 2 pills per month during one year) at baseline

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