Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among Men of African Descent: A case-control study

Table 2 Association between prostate cancer risk and selected GST gene variations

Gene	SNP	Case n (%)	Control n (%)	Risk Estimate^† OR (95% CI)	Risk Estimate^†† Adj OR (95% CI)	p-value^†††	p-value for Trend
GSTP1	AA (Ile/Ile)	55 (29.0)	186 (32.5)	1.00 (Reference)	1.00 (Reference)
A³¹³G	AG (Ile/Val)	85 (44.7)	274 (47.9)	1.12 (0.77-1.63)	1.09 (0.67-1.81)
Ile¹⁰⁵Val	GG(Val/Val)	50 (26.3)	112 (19.6)	1.62 (1.04-2.51)	1.66 (0.94-2.96)	0.141	0.080
	AG+GG	140 (73.7)	460 (80.4)	1.47 (1.00-2.15)	1.56 (0.95-2.58)	0.049
	missing	6 (3.2)	35 (6.1)
GSTM1	1/1 + 1/0	141 (75.0)	441 (76.3)	1.00 (Reference)	1.00 (Reference)
Deletion	0/0	47 (25.0)	137 (23.7)	1.07 (0.73-15.7)	1.08 (0.65-1.82)	0.718
	missing	8 (4.3)	29 (5.0)
GSTT1	1/1 + 1/0	153 (81.0)	482 (82.5)	1.00 (Reference)	1.00 (Reference)
Deletion	0/0	36 (19.0)	102 (17.5)	1.11 (0.73-1.69)	1.15 (0.66-2.02)	0.622
	missing	7 (3.7)	23 (3.9)

^†Associations were determined using multivariate logistic regression models to estimate the risk of developing PCA using GSTP1 105 Ile/Ile, GSTM1 *1/*1 + *1/*0 and GSTT1 *1/*1 + *1/*0 as the reference genotypes.
^††Risk estimates adjusted for age (continuous variable); prostate specific antigen (continuous variable); and West African Ancestry, WAA or admixture (continuous variable).
^†††Differences in the frequency of high-risk and low-risk genotypes between cases and controls were determined using the chi-square test of association with a significance level of 0.05.

ISSN: 1471-2407