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Table 2 Univariate and multivariate COX regression analysis

From: High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression

  Univariate analysis Multivariate analysisa
Factor Hazard ratiob P Hazard ratiob P
Egr-1     
Low expression (score 1) versus Egr-1 negative (score 0) 1.59 (1.01-2.50) 0.044 1.41 (0.89-2.24) 0.143
Moderate-high expression (score 2-3) versus Egr-1 negative (score 0) 1.95 (1.11-3.44) 0.021 1.38 (0.76-2.49) 0.285
Age (5 year intervals) 1.19 (1.08-1.31) 0.001 1.11 (0.99-1.25) 0.078
Tumor type (Papillary versus solid/mixed) 2.33 (1.43-3.80) 0.001 1.78 (1.03-3.08) 0.038
Tumor stage (T1 versus Ta) 3.01 (2.07-4.38) <0.001 0.42 (0.16-1.10) 0.078
Tumor grade (High grade versus PUNLMP+low grade) 3.42 (2.34-4.98) <0.001 6.12 (2.27-16.55) 0.000
Sex 0.99 (0.63-1.56) 0.981   
Size (> 3 cm versus < 3 cm) 1.02 (0.65-1.60) 0.941   
Bacillus Calmette-Guerin (BCG) treatment 0.55 (0.32-0.93) 0.026   
Concomitant CIS 1.02 (0.65-1.60) 0.941   
  1. aOnly risk factors that were significant (P < 0.01) in the univariate analysis was included in the multivariate analysis.
  2. bNumber in parentheses, 95% confidence intervals.