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Table 3 Stratified analysis according to potential confounding factors for 8q24 rs6983267 genotype

From: Association between an 8q24 locus and the risk of colorectal cancer in Japanese

   

rs6983267 allelic model

 
   

Model 1*1

  

Model*2

   

Exposure

Number of controls with each genotype (TT/TG/GG)

Number of cases with each genotype (TT/TG/GG)

OR*1

95% CI

p-value

OR

95% CI

p-value

Interaction P

Sex

        

0.181

Male

122/133/43

259/270/70

1.11

0.91-1.37

0.295

1.14

0.93-1.41

0.212

 

Female

61/89/30

159/166/37

1.44

1.10-1.88

0.007

1.34

1.01-1.78

0.040

 

Smoking

        

0.401

None

73/106/35

206/232/55

1.34

1.05-1.70

0.018

1.29

1.01-1.65

0.042

 

Low-moderate (< 20 pack-years)

19/31/9

52/52/12

1.51

0.93-2.43

0.094

1.49

0.89-2.49

0.130

 

Heavy (≥ 20 pack-years)

88/84/29

158/147/39

1.11

0.86-1.43

0.423

1.12

0.86-1.44

0.407

 

Drinking

        

0.437

None

69/92/30

166/179/38

1.36

1.04-1.76

0.023

1.35

1.03-1.77

0.028

 

Low (< 5 g ethanl/day)

23/29/12

51/58/16

1.25

0.81-1.93

0.308

1.44

0.91-2.28

0.124

 

Moderate (5≤ and < 23 g ethanol/day)

34/41/9

85/83/27

0.98

0.67-1.43

0.918

0.99

0.67-1.46

0.941

 

High (≥ 23 g ethanol/day)

55/59/19

112/108/23

1.22

0.89-1.67

0.217

1.22

0.88-1.69

0.231

 

Daily folate consumption

        

0.694

T1 (≤ 262.0 μg/day)

54/73/25

112/137/37

1.14

0.85-1.53

0.375

1.22

0.90-1.66

0.197

 

T2 (≤ 346.6 μg/day)

59/75/22

104/141/36

1.21

0.91-1.61

0.191

1.25

0.93-1.67

0.141

 

T3 (> 346.6 μg/day)

66/72/24

157/152/32

1.24

0.94-1.64

0.135

1.30

0.97-1.73

0.080

 

Body-Mass Index (BMI) kg/m 2

        

0.678

< 22.5

73/100/32

177/176/44

1.34

1.05-1.72

0.020

1.43

1.10-1.85

0.007

 

22.5 ≤ and < 25

69/69/19

128/148/37

0.93

0.70-1.25

0.663

0.93

0.69-1.25

0.637

 

25 ≤ and < 27.5

23/34/16

74/69/19

1.58

1.06-2.36

0.024

1.67

1.09-2.55

0.018

 

≥ 27.5

18/17/5

31/41/7

0.98

0.54-1.79

0.944

1.06

0.54-2.10

0.863

 

Family history of colorectal cancer in the first degree relatives

        

0.765

No

169/212/69

404/422/105

1.24

1.05-1.46

0.011

1.26

1.06-1.48

0.008

 

Yes

14/10/4

14/14/2

1.09

0.50-2.38

0.833

0.84

0.29-2.43

0.741

 

Average recreational exercise

        

0.109

None

77/90/24

161/140/48

1.10

0.85-1.42

0.462

1.13

0.87-1.47

0.356

 

< 0.5 hour/day

73/89/31

158/199/40

1.20

0.93-1.56

0.163

1.20

0.92-1.57

0.174

 

0.5 ≤ hour/day

33/43/18

99/97/19

1.59

1.11-2.28

0.012

1.70

1.15-2.50

0.008

 
  1. *1 Odds ratios were adjusted for age and sex in unconditional logistic regression models. Conditional logistic models were not applied because keeping matching in stratficiation gave unstabel estimation.
  2. *2 Odds ratio adjusted for age, sex and all variables in this examination except variable used for stratification.
  3. *3 Interaction term between rs6983267 genotype in score and stratifiying factor in socre was added in model 2.
  4. *4 Subjects were exlucded from analysis because of lack of information, smoking (4 cases and 8 controls), drinking (7 cases and 15 controls), folate (8 cases and 17 controls), and BMI (3 cases and 10 controls)
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BMC Cancer

ISSN: 1471-2407

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