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Table 3 Risk for second esophageal cancer by follow-up interval after the diagnosis of oral/pharyngeal cancer.

From: The incidence and risk of developing a second primary esophageal cancer in patients with oral and pharyngeal carcinoma: a population-based study in Taiwan over a 25 year period

First primary cancer site (ICD-9)

Follow-up time (yrs)

OPY

O

E

SIR

(O/E)

95% CI

Oral cavity

(140-1,143-145)

≤1

10352

34

1.87

18.18

(12.62-25.47)

 

1-5

25205

45

4.91

9.16

(6.69-12.27)

 

> 5

55087

20

10.96

1.82

(1.11--2.82)

Oropharynx

(146, 149)

≤1

1449

21

0.28

75.00

(47.12-116.41)

 

1-5

2862

9

0.53

17.31

(7.83-32.56)

 

> 5

6992

0

1.30

0

(NA)

Hypopharynx

(148)

≤1

2119

43

0.53

81.13

(59.57-110.88)

 

1-5

3005

20

0.77

25.97

(15.76-39.87)

 

> 5

6088

8

1.82

4.40

(1.89 -- 8.66)

  1. Bold indicates statistical significance.
  2. OPY = observed person years; SIR = standardized incidence ratio; O = observed numbers of second esophageal cancer; E = expected numbers of second esophageal cancer; CI = confidence interval;
  3. NA = not assessable; yrs = years.