Selecting for BRCA1 testing using a combination of homogeneous selection criteria and immunohistochemical characteristics of breast cancers

Table 5 Relation between breast cancer receptorial status and BRCA1 mutant genotype.

Receptorial status	BRCA1 carriers	non-BRCA1 cases	Total
° ER- and/or PR-	10	19	29
ER+/PR+	-	64	64
Total	10	83	93

Sensitivity 100%; Specificity 77.1%; Predictive Positive Value 34.4%; Predictive Negative Value 100%; ° IHC Allred total scores of 3 or more were reported as positive.

ISSN: 1471-2407