Selecting for BRCA1 testing using a combination of homogeneous selection criteria and immunohistochemical characteristics of breast cancers

Miolo, GianMaria; Canzonieri, Vincenzo; De Giacomi, Clelia; Puppa, Lara Della; Dolcetti, Riccardo; Lombardi, Davide; Perin, Tiziana; Scalone, Simona; Veronesi, Andrea; Viel, Alessandra

doi:10.1186/1471-2407-9-360

Table 4 non BRCA1/2 mutation group and IHC tumour characteristics.

From: Selecting for BRCA1 testing using a combination of homogeneous selection criteria and immunohistochemical characteristics of breast cancers

ID pts	Age at diagnosis	Grade	° ER (score)	° PR (score)	§HER2	^ BRCAPRO BRCA1	^ BRCAPRO BRCA2	^ BRCAPRO total	*BC, CBC and BBC cases	*OC cases
BR271	40	G2	+ (7)	+ (5)	1+/2+	0.002	0.036	0.038	1 (37)	/
BR275	28 BBC	G3	+ (7)	+ (7)	-	0.067	0.578	0.645	1 (55)	/
BR281	42	G3	+ (6)	+ (4)	3+	0.008	0.222	0.230	6 (27, 36, 50, 60, 50 BBC, 60)	/
BR297	54	G3	- (0)	- (0)	-	0.064	0.018	0.081	2 (42, 69)	/
BR304	41	G3	+ (7)	+ (6)	-	0.002	0.058	0.060	2 (52, 64)	/
BR315	46 BBC	G2	+ (7)	+ (7)	1+	0.012	0.160	0.172	1 (49)	/
BR335	64	G2	+ (8)	- (0)	1+	0.002	0.017	0.020	2 (57, 70)	1 (69)
BR338	36	G3	- (0)	- (0)	3+	0.131	0.029	0.160	2 (45, 71)	/
BR339	74	G2	+ (7)	+ (7)	-	0.003	0.085	0.088	3 (39, 61+63 CBC, 66)	2 (54, 64)
BR340	35	G3	+ (7)	- (0)	3+	0.009	0.026	0.035	2 (43, 59)	/
BR348	55	G3	+ (7)	- (0)	1+	0.009	0.062	0.071	2 (56, 56)	1 (68)
BR350	42	G3	+ (7)	+ (7)	2+	0.001	0.014	0.015	4 (49, 57, 61, 70)	/
BR357	35	G3	+ (6)	- (0)	-	0.002	0.014	0.016	2 (55, 67)	/
BR377	46	G3	+ (7)	+ (6)	-	0.000	0.007	0.007	2 (46, 70)	/
BR380	30	G2	- (0)	- (0)	1+/2+	0.303	0.067	0.370	3 (42, 64, 64)	/
BR381	45	G3	+ (5)	+ (6)	-	0.000	0.004	0.004	2 (45, 85)	/
BR398	50	G2	+ (5)	+ (3)	-	0.000	0.020	0.020	5 (60, 61, 65, 70, 98)	/
BR403	53+57 CBC	G3	+ (7)	+ (7)	-	0.000	0.006	0.007	1 (82+84 CBC)	/
BR408	53	G2	+ (6)	+ (4)	-	0.000	0.002	0.002	3 (71, 85, 67°)	/
BR414	60	G2	- (2)	+ (4)	-	0.003	0.101	0.104	2 (73M, 50)	/
BR418	27	G3	- (0)	- (0)	3+	0.093	0.015	0.108	/	/
BR422	55	G3	+ (6)	- (2)	-	0.002	0.014	0.016	2 (50, 53)	/
BR424	45	G2	+ (5)	+ (7)	2+	0.006	0.113	0.119	1 (49+59 CBC)	/
BR425	27	G2	+ (3)	+ (5)	3+	0.001	0.012	0.013	/	/
BR439	52	G3	- (0)	- (2)	-	0.052	0.030	0.082	3 (36, 60, 70)	1 (78)
BR445	54	G1	+ (6)	+ (3)	1+	0.004	0.067	0.072	2 (45, 48+52 CBC)	/
BR446	50	G2	+ (7)	+ (4)	1+	0.000	0.008	0.008	1 (40)	/
BR447	65	G2	+ (8)	+ (6)	-	0.001	0.045	0.046	2 (58, 79)	/
BR449	50	G2	+ (6)	+ (7)	-	0.001	0.020	0.021	1 (37)	/
BR457	53	G3	+ (4)	- (2)	3+	0.000	0.003	0.004	2 (55, 55)	/
BR463	48	G3	+ (6)	+ (5)	-	0.001	0.032	0.033	1 (67 BBC)	/
BR480	53	G2	+ (7)	+ (7)	-	0.004	0.135	0.139	3 (31, 50, 53)	/
BR484	57	G2	+ (7)	+ (7)	1+	0.000	0.014	0.014	2 (55, 73+78 CBC)	/
BR494	58	G3	+ (5)	- (0)	-	0.020	0.352	0.372	4 (40, 43, 45, NA M)	/
BR498	46	G2	+ (5)	+ (7)	-	0.005	0.837	0.841	4 (42 BBC, 48, 49M, 74)	/
BR506	55	G1	- (0)	+ (5)	-	0.000	0.012	0.012	3 (62, 30, 76)	/
BR535	56	G3	+ (7)	+ (7)	1+	0.000	0.019	0.019	3 (47, 53, NA)	/
BR542	45	G3	+ (7)	+ (7)	1+	0.007	0.112	0.119	2 (36,62)	/
BR545	63	G2	+ (7)	+ (6)	1+	0.000	0.003	0.003	2 (64, 70)	/
BR549	36	G3	+ (6)	+ (5)	1+	0.013	0.142	0.155	1 (36)	/
BR553	54	G2	+ (7)	+ (6)	1+	0.011	0.486	0.497	2 (49, 65)	1 (55)
BR558	45	G1	+(7)	+ (8)	1+	0.000	0.029	0.030	3 (48, 78, 78)	/
BR560	78	G2	+ (7)	+ (3)	1+	0.000	0.025	0.025	3 (45, 48, 78)	/
BR569	41	G2	+ (7)	+ (8)	-	0.114	0.072	0.185	/	2 (60, 60)
BR582	27	G3	+ (6)	+ (8)	-	0.001	0.016	0.016	/	/
BR584	42	/	+ (5)	+ (6)	1+	0.001	0.017	0.018	3 (40, 54, 69)	/
BR592	67	G2	+(7)	+(7)	2+	0.001	0.035	0.036	4 (48, 52, 55, 60)	/
BR593	48	G3	+(7)	+ (3)	1+	0.088	0.242	0.330	3 (33 BBC, 65, 70)	1 (24)
BR599	39+44 CBC	G3	+ (6)	- (0)	3+	0.187	0.370	0.557	2 (44, 60)	/
BR603	40	G2	+ (7)	+ (7)	-	0.001	0.032	0.033	1 (36)	/
BR615	49	G1	+ (7)	+ (7)	1+	0.000	0.004	0.004	2 (49, 50)	/
BR649	80	G2	+ (7)	+ (6)	1+	0.001	0.404	0.406	2 (31, 44 BBC)	/
BR650	47	G3	+ (6)	- (0)	-	0.004	0.017	0.021	1 (45)	/
BR656	43	G2	+ (6)	+ (7)	1+	0.003	0.269	0.272	3 (40, 44, 52)	/
BR666	56	G2	+ (8)	+ (6)	1+	0.132	0.201	0.332	3 (39, 50, 51)	3 (49, 54, 61)

BC = breast cancer; CBC = controlateral breast cancer; OC = ovarian cancer; / = no cases; M = male. The ages at diagnosis of the first cousins are in boldface type; ° IHC Allred total scores of 3 or more were reported as positive. §HER2 IHC scores: - negative, 1+ weak, 2+ moderate, 3+ strong. ^ Probability of mutation calculated by BRCAPRO software http://www.isds.duke.edu/~gp/brcapro.html; * number of additional tumours in the family and ages of onset in parentheses.

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