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Table 4 Multivariate Cox models for the association between gene methylation and cancer survival/cancer recurrence

From: Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation

   Hazard Ratio  
  MGMT CDKN2A RASSF1
Overall Survival    
   Unmethylated 1 (reference) 1 (reference) 1 (reference)
   Methylated 2.17 (1.11-4.23)A 1.41 (0.35-5.75)C 0.88 (0.20-3.84)C
< 6.9% Methylated 1.52 (0.59-3.91)B not evaluated not evaluated
≥ 6.9% Methylated 4.38 (1.78-10.76)B not evaluated not evaluated
Test of trend p = 0.002 --- ---
Disease-Free Survival    
   Unmethylated 1 (reference) 1 (reference) 1 (reference)
   Methylated 3.49 (1.62-7.52)D 2.57 (0.47-14.12)C 2.54 (0.82-7.93)C
< 6.9% Methylated 3.03 (1.24-7.44)B not evaluated not evaluated
≥ 6.9% Methylated 5.46 (1.75-17.00)B not evaluated not evaluated
Test of trend p = 0.001 --- ---
  1. A Adjusted for age, smoking, alcohol use, and stage at diagnosis
  2. B Adjusted for age, gender, alcohol use, and stage at diagnosis
  3. C Adjusted for age, alcohol use, and stage at diagnosis
  4. D Adjusted for age, smoking, alcohol use, treatment, and stage at diagnosis