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Table 4 Multivariate Cox models for the association between gene methylation and cancer survival/cancer recurrence

From: Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation

  

Hazard Ratio

 
 

MGMT

CDKN2A

RASSF1

Overall Survival

   

   Unmethylated

1 (reference)

1 (reference)

1 (reference)

   Methylated

2.17 (1.11-4.23)A

1.41 (0.35-5.75)C

0.88 (0.20-3.84)C

< 6.9% Methylated

1.52 (0.59-3.91)B

not evaluated

not evaluated

≥ 6.9% Methylated

4.38 (1.78-10.76)B

not evaluated

not evaluated

Test of trend

p = 0.002

---

---

Disease-Free Survival

   

   Unmethylated

1 (reference)

1 (reference)

1 (reference)

   Methylated

3.49 (1.62-7.52)D

2.57 (0.47-14.12)C

2.54 (0.82-7.93)C

< 6.9% Methylated

3.03 (1.24-7.44)B

not evaluated

not evaluated

≥ 6.9% Methylated

5.46 (1.75-17.00)B

not evaluated

not evaluated

Test of trend

p = 0.001

---

---

  1. A Adjusted for age, smoking, alcohol use, and stage at diagnosis
  2. B Adjusted for age, gender, alcohol use, and stage at diagnosis
  3. C Adjusted for age, alcohol use, and stage at diagnosis
  4. D Adjusted for age, smoking, alcohol use, treatment, and stage at diagnosis
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BMC Cancer

ISSN: 1471-2407

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