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Table 3 Two-way SNP interaction effects on breast cancer risk.

From: Association of common variants in mismatch repair genes and breast cancer susceptibility: a multigene study

Two-way SNP Interactions Genotypes Controls Cases All cases
MSH3 Ala1045Thr (A>G)/MSH6 Gly39Glu (C>T)   Controls n (%) Cases n (%) Crude OR (95% CI) P value Adjusted OR (95% CI) a P value
  GG/CC 29 (5.3%) 26 (9.1%) 1 (Reference) 0.36 1 (Reference) 0.26
  AA/TT AG/TT GG/TT GG/TC 43 (7.9%) 22 (7.7%) 0.57 (0.27-1.19) 0.14 0.53 (0.25-1.13) 0.10
  AA/TC 81 (14.9%) 33 (11.5%) 0.45 (0.23-0.89) 0.02 0.43 (0.21-0.83) 0.01
  AA/CC 158 (29.1%) 83 (29.0%) 0.59 (0.32-1.06) 0.08 0.55 (0.30-1.00) 0.05
  AG/TC 66 (12.2%) 36 (12.6%) 0.61 (0.31-1.19) 0.14 0.61 (0.310-1.21) 0.16
  AG/CC 166 (30.6%) 86 (30.1%) 0.58 (0.32-1.04) 0.07 0.55 (0.30-1.01) 0.05
MSH4 Ala97Thr (A>G)/ MLH3 Leu844Pro (G>A)   Controls n (%) Cases n (%) Crude OR (95% CI) P value Adjusted OR (95% CI) a P value
  GG/GG 85 (15.6%) 28 (9.8%) 1 (Reference) 0.02 1 (Reference) 0.01
  AA/AA AA/AG AA/GG 46 (8.5%) 24 (8.4%) 1.58 (0.83-3.04) 0.17 1.70 (0.87-3.32) 0.12
  AG/AA 41 (7.5%) 31 (10.8%) 2.30 (1.22-4.32) 0.01 2.35 (1.23-4.49) 0.01
  AG/AG 127 (23.3%) 47 (16.4%) 1.12 (0.65-1.93) 0.67 1.03 (0.59-1.78) 0.93
  AG/GG 71 (13.1%) 39 (13.6%) 1.67 (0.94-2.98) 0.08 1.54 (0.85-2.78) 0.15
  GG/AA 44 (8.1%) 32 (11.2%) 2.21 (1.18-4.12) 0.01 2.11 (1.12-3.98) 0.02
  GG/AG 130 (23.9%) 85 (29.7%) 1.99 (1.20-3.30) 0.01 1.88 (1.12-3.15) 0.02
  1. a ORs were adjusted for: age at diagnosis (≤30, 31 -49, 50-69, and ≥70 years), the lower age group being the referent class; alcohol consumption (never, social, and regular drinkers), never drinkers being the referent group; and smoking habits (smokers/non-smokers), non-smokers being the referent group.
  2. Data in bold highlights the statistic significant results. P values are adjusted by unconditional multiplicative logistic regression.