Table 3 Two-way SNP interaction effects on breast cancer risk.
Two-way SNP Interactions | Genotypes | Controls | Cases | All cases | |||
|---|---|---|---|---|---|---|---|
MSH3 Ala1045Thr (A>G)/MSH6 Gly39Glu (C>T) | Controls n (%) | Cases n (%) | Crude OR (95% CI) | P value | Adjusted OR (95% CI) a | P value | |
GG/CC | 29 (5.3%) | 26 (9.1%) | 1 (Reference) | 0.36 | 1 (Reference) | 0.26 | |
AA/TT AG/TT GG/TT GG/TC | 43 (7.9%) | 22 (7.7%) | 0.57 (0.27-1.19) | 0.14 | 0.53 (0.25-1.13) | 0.10 | |
AA/TC | 81 (14.9%) | 33 (11.5%) | 0.45 (0.23-0.89) | 0.02 | 0.43 (0.21-0.83) | 0.01 | |
AA/CC | 158 (29.1%) | 83 (29.0%) | 0.59 (0.32-1.06) | 0.08 | 0.55 (0.30-1.00) | 0.05 | |
AG/TC | 66 (12.2%) | 36 (12.6%) | 0.61 (0.31-1.19) | 0.14 | 0.61 (0.310-1.21) | 0.16 | |
AG/CC | 166 (30.6%) | 86 (30.1%) | 0.58 (0.32-1.04) | 0.07 | 0.55 (0.30-1.01) | 0.05 | |
MSH4 Ala97Thr (A>G)/ MLH3 Leu844Pro (G>A) | Controls n (%) | Cases n (%) | Crude OR (95% CI) | P value | Adjusted OR (95% CI) a | P value | |
GG/GG | 85 (15.6%) | 28 (9.8%) | 1 (Reference) | 0.02 | 1 (Reference) | 0.01 | |
AA/AA AA/AG AA/GG | 46 (8.5%) | 24 (8.4%) | 1.58 (0.83-3.04) | 0.17 | 1.70 (0.87-3.32) | 0.12 | |
AG/AA | 41 (7.5%) | 31 (10.8%) | 2.30 (1.22-4.32) | 0.01 | 2.35 (1.23-4.49) | 0.01 | |
AG/AG | 127 (23.3%) | 47 (16.4%) | 1.12 (0.65-1.93) | 0.67 | 1.03 (0.59-1.78) | 0.93 | |
AG/GG | 71 (13.1%) | 39 (13.6%) | 1.67 (0.94-2.98) | 0.08 | 1.54 (0.85-2.78) | 0.15 | |
GG/AA | 44 (8.1%) | 32 (11.2%) | 2.21 (1.18-4.12) | 0.01 | 2.11 (1.12-3.98) | 0.02 | |
GG/AG | 130 (23.9%) | 85 (29.7%) | 1.99 (1.20-3.30) | 0.01 | 1.88 (1.12-3.15) | 0.02 | |