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Table 3 Multivariate Cox regression analysis.

From: Topoisomerase I but not thymidylate synthase is associated with improved outcome in patients with resected colorectal cancer treated with irinotecan containing adjuvant chemotherapy

 

OS

DFS

 

HR

95% CI

p

HR

95% CI

p

Stage

      

   Dukes B

1

-

 

1

-

 

   Dukes C

2.75

1.84-4.12

<0.001

2.46

1.74-3.48

<0.001

Differentiation grade

      

   Well or Moderate

1

-

 

1

-

 

   Poor

2.51

1.60-3.94

<0.001

2.56

1.73-3.79

<0.001

TS expression

      

   Negative/Low expression

1

-

 

1

-

 

   Positive/High

1.37

0.94-1.97

0.098

1.32

0.95-1.82

0.097

Topo I expression

      

   Negative/Low expression

1

-

 

1

-

 

   Positive/High

0.61

0.42-0.88

0.009

0.80

0.58-1.11

0.180

CPT-11 treatment

      

   No

1

-

 

1

-

 

   Yes

0.78

0.52-1.16

0.216

0.79

0.56-1.12

0.187

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BMC Cancer

ISSN: 1471-2407

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