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Table 3 Multivariate Cox regression analysis.

From: Topoisomerase I but not thymidylate synthase is associated with improved outcome in patients with resected colorectal cancer treated with irinotecan containing adjuvant chemotherapy

  OS DFS
  HR 95% CI p HR 95% CI p
Stage       
   Dukes B 1 -   1 -  
   Dukes C 2.75 1.84-4.12 <0.001 2.46 1.74-3.48 <0.001
Differentiation grade       
   Well or Moderate 1 -   1 -  
   Poor 2.51 1.60-3.94 <0.001 2.56 1.73-3.79 <0.001
TS expression       
   Negative/Low expression 1 -   1 -  
   Positive/High 1.37 0.94-1.97 0.098 1.32 0.95-1.82 0.097
Topo I expression       
   Negative/Low expression 1 -   1 -  
   Positive/High 0.61 0.42-0.88 0.009 0.80 0.58-1.11 0.180
CPT-11 treatment       
   No 1 -   1 -  
   Yes 0.78 0.52-1.16 0.216 0.79 0.56-1.12 0.187