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Table 2 Estimated effect of early detection of breast cancer (BC), in the 40-80 year age interval, with different BC survival scenarios.

From: Effectiveness of early detection on breast cancer mortality reduction in Catalonia (Spain)

  Scenario A Scenario B Scenario C
Interval of exams Annual Biennial Annual Biennial Annual Biennial
  MR (%)
40-74 29.8 22.9 32.5 25.1 44.0 33.8
50-69 25.3 19.6 27.6 21.3 36.7 27.6
  YLG per woman screened
40-74 0.222 0.165 0.203 0.151 0.208 0.154
50-69 0.176 0.132 0.161 0.120 0.162 0.119
  YLG per breast cancer detected
40-74 1.874 1.387 1.711 1.272 1.753 1.300
50-69 1.485 1.109 1.353 1.010 1.367 1.003
  1. Relative BC mortality reduction (MR) and years of life gained (YLG). Catalonia, cohorts born in 1955-59.
  2. A: Survival probability density functions (pdfs): Catalonia 1980-1989 (pre-dissemination of mammography screening).
  3. B: Resulting survival pdfs after applying a hazard ratio of 0.75 to the 1980-1989 hazard rates, in order to take into account the effect of adjuvant treatments.
  4. C: Survival pdfs: Catalonia 1990-2001 (survival functions have not been corrected by the lead time bias that originates from earlier detection). This scenario produces an overestimation of the effect of early detection.