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Table 2 Multivariate logistic regression analysis of clinical parameters associated with CD133 expression in HCC.

From: CD133-positive hepatocellular carcinoma in an area endemic for hepatitis B virus infection

Clinicopathological parameters

CD133 expression in HCC

Unadjusted OR

(95% CI)a

Adjusted OR

(95% CI)b

 

Positive

(n = 24)

Negative

(n = 130)

  

Age (years)

53.6 ± 15.3

56.7 ± 14.9

0.983 (0.959 - 1.010)

0.997 (0.943 - 1.055)

Sex (male)

18 (75.0%)

96 (74.8%)

1.063 (0.358 - 3.282)

0.621 (0.109 - 3.542)

HBsAg (positive)

11 (45.8%)

93 (71.5%)

0.337 (0.126 - 0.890)c

0.084 (0.010 - 0.707)d

Anti-HCV (positive)

6 (25.0%)

36 (27.7%)

0.870 (0.283 - 2.575)

0.295 (0.027 - 3.192)

Cirrhosis (yes)

11 (45.8%)

62 (47.7%)

0.928 (0.356 - 2.410)

1.630 (0.324 - 8.188)

Alcoholism (yes)

6 (25.0%)

37 (28.5%)

0.838 (0.272 - 2.474)

1.135 (0.212 - 6.061)

Creatinine (mg/dL)

1.0 ± 0.2

1.3 ± 1.6

0.324 (0.048 - 2.202)

0.849 (0.167 - 4.305)

Tumor characteristics

    

   Microvascular invasion (yes)

11 (45.8%)

35 (26.9%)

2.297 (0.862 - 6.110)

10.560 (1.312 - 84.994)

   Edmondson's grading (> 2)

18 (75.0%)

77 (59.2%)

2.065 (0.710 - 6.271)

6.315 (0.758 - 52.618)

   Encapsulation (yes)

17 (70.8%)

99 (76.2%)

0.760 (0.265 - 2.243)

1.775 (0.285 - 11.055)

   Tumor number (> 2)

9 (37.5%)

21 (16.2%)

3.114 (1.088 - 8.867)e

2.933 (0.561 - 15.334)

   Microsatellites (yes)

7 (29.2%)

20 (15.4%)

2.265 (0.740 - 6.794)

2.032 (0.185 - 22.347)

   Tumor size (Diameter, cm)

8.0 ± 5.2

6.7 ± 4.6

1.057 (0.970 - 1.152)

0.881 (0.700 - 1.110)

   Portal Vein Thrombosis (yes)

3 (12.5%)

10 (7.7%)

1.741 (0.341 - 7.616)

0.893 (0.094 - 8.487)

   Alpha-fetoprotein (100 ng/mL)

70.3 ± 394.6

31.3 ± 55.6

1.000 (0.997 - 1.002)

0.996 (0.988 - 1.003)

Liver Function

    

   Albumin (g/dL)

3.7 ± 0.6

3.8 ± 0.7

0.881 (0.446 - 1.742)

1.493 (0.409 - 5.456)

   Bilirubin (mg/dL)

1.2 ± 0.9

1.3 ± 1.8

0.950 (0.688 - 1.310)

1.032 (0.588 - 1.812)

   Prothrombin time (sec)

12.2 ± 1.2

12.5 ± 1.6

0.876 (0.623 - 1.232)

0.905 (0.563 - 1.456)

   Ascites (yes)

2 (8.3%)

12 (9.2%)

0.894 (0.129 - 4.693)

1.140 (0.103 - 12.576)

Liver necroinflammation

    

   AST (U/L)

117.3 ± 202.2

91.1 ± 98.3

1.002 (0.998 - 1.005)

1.009 (0.998 - 1.019)

   ALT (U/L)

72.3 ± 116.9

75.6 ± 91.9

1.000 (0.995 - 1.005)

0.997 (0.987 - 1.007)

  1. aUnadjusted odds ratios were calculated using regression analysis for parametric data and chi-square test for categorical data.
  2. bOdds ratios adjusted for all other variables in this table; cP = 0.025; dP = 0.023; eP = 0.032.
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BMC Cancer

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