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Table 2 Multivariate logistic regression analysis of clinical parameters associated with CD133 expression in HCC.

From: CD133-positive hepatocellular carcinoma in an area endemic for hepatitis B virus infection

Clinicopathological parameters CD133 expression in HCC Unadjusted OR
(95% CI)a
Adjusted OR
(95% CI)b
  Positive
(n = 24)
Negative
(n = 130)
  
Age (years) 53.6 ± 15.3 56.7 ± 14.9 0.983 (0.959 - 1.010) 0.997 (0.943 - 1.055)
Sex (male) 18 (75.0%) 96 (74.8%) 1.063 (0.358 - 3.282) 0.621 (0.109 - 3.542)
HBsAg (positive) 11 (45.8%) 93 (71.5%) 0.337 (0.126 - 0.890)c 0.084 (0.010 - 0.707)d
Anti-HCV (positive) 6 (25.0%) 36 (27.7%) 0.870 (0.283 - 2.575) 0.295 (0.027 - 3.192)
Cirrhosis (yes) 11 (45.8%) 62 (47.7%) 0.928 (0.356 - 2.410) 1.630 (0.324 - 8.188)
Alcoholism (yes) 6 (25.0%) 37 (28.5%) 0.838 (0.272 - 2.474) 1.135 (0.212 - 6.061)
Creatinine (mg/dL) 1.0 ± 0.2 1.3 ± 1.6 0.324 (0.048 - 2.202) 0.849 (0.167 - 4.305)
Tumor characteristics     
   Microvascular invasion (yes) 11 (45.8%) 35 (26.9%) 2.297 (0.862 - 6.110) 10.560 (1.312 - 84.994)
   Edmondson's grading (> 2) 18 (75.0%) 77 (59.2%) 2.065 (0.710 - 6.271) 6.315 (0.758 - 52.618)
   Encapsulation (yes) 17 (70.8%) 99 (76.2%) 0.760 (0.265 - 2.243) 1.775 (0.285 - 11.055)
   Tumor number (> 2) 9 (37.5%) 21 (16.2%) 3.114 (1.088 - 8.867)e 2.933 (0.561 - 15.334)
   Microsatellites (yes) 7 (29.2%) 20 (15.4%) 2.265 (0.740 - 6.794) 2.032 (0.185 - 22.347)
   Tumor size (Diameter, cm) 8.0 ± 5.2 6.7 ± 4.6 1.057 (0.970 - 1.152) 0.881 (0.700 - 1.110)
   Portal Vein Thrombosis (yes) 3 (12.5%) 10 (7.7%) 1.741 (0.341 - 7.616) 0.893 (0.094 - 8.487)
   Alpha-fetoprotein (100 ng/mL) 70.3 ± 394.6 31.3 ± 55.6 1.000 (0.997 - 1.002) 0.996 (0.988 - 1.003)
Liver Function     
   Albumin (g/dL) 3.7 ± 0.6 3.8 ± 0.7 0.881 (0.446 - 1.742) 1.493 (0.409 - 5.456)
   Bilirubin (mg/dL) 1.2 ± 0.9 1.3 ± 1.8 0.950 (0.688 - 1.310) 1.032 (0.588 - 1.812)
   Prothrombin time (sec) 12.2 ± 1.2 12.5 ± 1.6 0.876 (0.623 - 1.232) 0.905 (0.563 - 1.456)
   Ascites (yes) 2 (8.3%) 12 (9.2%) 0.894 (0.129 - 4.693) 1.140 (0.103 - 12.576)
Liver necroinflammation     
   AST (U/L) 117.3 ± 202.2 91.1 ± 98.3 1.002 (0.998 - 1.005) 1.009 (0.998 - 1.019)
   ALT (U/L) 72.3 ± 116.9 75.6 ± 91.9 1.000 (0.995 - 1.005) 0.997 (0.987 - 1.007)
  1. aUnadjusted odds ratios were calculated using regression analysis for parametric data and chi-square test for categorical data.
  2. bOdds ratios adjusted for all other variables in this table; cP = 0.025; dP = 0.023; eP = 0.032.