From: Clinical significance of altered nm23-H1, EGFR, RB and p53 expression in bilharzial bladder cancer
 |  | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|---|
Predictive variables | CS | HR | CI | p | HR | CI | p |
Age | Â | Â | Â | Â | Â | Â | Â |
   <47 | 68% | 1 | 0.99, 1.02 | 0.880 |  |  |  |
   ≥ 47 * | 66% |  |  |  |  |  |  |
Sex: | Â | Â | Â | Â | Â | Â | Â |
Male (42) | 59% | 1.1 | 0.85, 1.04 | 0.652 | Â | Â | Â |
Female (17) | 64% | Â | Â | Â | Â | Â | Â |
Tumor type | Â | Â | Â | Â | Â | Â | Â |
SCC (27) | 60% | 1.212, | 0.538, 2.734 | 0.643 | Â | Â | Â |
TCC (27) | 65% | Â | Â | Â | Â | Â | Â |
Adenocarcinoma (5) | 60% | Â | Â | Â | Â | Â | Â |
Tumor grade | Â | Â | Â | Â | Â | Â | Â |
I (5) | 66% | 1.96 | 1.66, 21.331 | <0.000 | 4.350 | 1.786, 10.591 | 0.001 |
II (39) | 32% | Â | Â | Â | Â | Â | Â |
III (15) | 11% | Â | Â | Â | Â | Â | Â |
Lymph Node Involvement: | Â | 1.099 | 0.423, 2.859 | 0.846 | Â | Â | Â |
Positive (10) | 49% | Â | Â | Â | Â | Â | Â |
Negative (49) | 55% | Â | Â | Â | Â | Â | Â |
Metastatic recurrence: | Â | Â | Â | Â | Â | Â | Â |
No (33) | 58% | 14.149 | 5.117, 39.123 | 0.000 | 14.903 | 5.315, 41.785 | 0.000 |
Yes (21) | 25% | Â | Â | Â | Â | Â | Â |
Pathological Stage: | Â | Â | Â | Â | Â | Â | Â |
p2 & pp3a (27) | 49% | 1.341 | 0.575, 3.127 | 0.498 | Â | Â | Â |
p3b &p4 (32) | 35% | Â | Â | Â | Â | Â | Â |
Nm23 (IHC ) | Â | Â | Â | Â | Â | Â | Â |
Positive (34) | 66.5% | 1.62 | 0.535, 2.244 | 0.345 | Â | Â | Â |
Negative (25) | 59.6% | Â | Â | Â | Â | Â | Â |
nm23(RNA ) | Â | Â | Â | Â | Â | Â | Â |
   Positive (33) | 64.8% | 1.34 | 1.20, 1.50 | 0.021 | 0.695 | 0.586, 1.975 | 0.444 |
   Negative (19) | 35.5% |  |  |  |  |  |  |
EGFR (IHC) | Â | Â | Â | Â | Â | Â | Â |
   Positive (39) | 41% | 1.61 | 1.04, 2.29 | 0.034 | 3.576 | 1.206, 10.602 | 0.022 |
   Negative (20) | 69% |  |  |  |  |  |  |
EGFR (RNA) | Â | Â | Â | Â | Â | Â | Â |
   Positive (32) | 39% | 1.69 | 1.16, 2.74 | 0.031 | 3.911 | 1.148, 8.511 | 0.025 |
   Negative (20) | 69% |  |  |  |  |  |  |
Rb | Â | Â | Â | Â | Â | Â | Â |
   Positive (25) | 54% | 1.1 | 0.27, 1.76 | 0.287 |  |  |  |
   Negative (34) | 49% |  |  |  |  |  |  |
p53 (IHC) | Â | Â | Â | Â | Â | Â | Â |
   Positive (21) | 29% | 3.9 | 2.281, 12.42 | 0.011 | 2.512 | 0.948, 6.662 | 0.64 |
   Negative (38) | 60% |  |  |  |  |  |  |
P53 (mutations) | Â | Â | Â | Â | Â | Â | Â |
   Positive (8) |  |  |  | 0.539 |  |  |  |
   Negative (51) |  |  |  |  |  |  |  |
Number of abnormal genes | Â | 1.70 | 1.20, 5.90 | 0.022 | 7.331 | 2.696, 12.940 | 0.001 |
   <2 |  |  |  |  |  |  |  |
   ≥ 2 |  |  |  |  |  |  |  |