Cripto-1 gene silencing suppresses cell proliferation in vivo. (a) representative mouse bearing tumors (up was in CNE-2 control group, down was in CNE-2/GFP+/Cripto-1- group). (b) external whole-body fluorescence images of the same mouse. (c) the external images of xenotransplant tumors (top was in CNE-2/GFP+/Cripto-1- group, bottom was in CNE-2 control group). (d) H&E stains of xenotransplant tumors, (×400). (e) expression of Ki67 in xenotransplant tumors of CNE-2 control group (×400). (f) expression of Ki67 in xenotransplant tumors of CNE-2/GFP+/Cripto-1- group (×400).