Table 2 TCF7L2 rs12255372 and risk of ovarian cancer
From: No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer
N | N | Ordinal OR (95% CI) | Co-Dominant ORs (95% CI) | |||||
|---|---|---|---|---|---|---|---|---|
Cases | Controls | Per T-allele | P (trend) | GT v GG | TT v GG | P (2 d.f.) | ||
Total | --- | 391 | 458 | 0.96 (0.77-1.20) | 0.75 | 0.95 (0.71-1.26) | 0.97 (0.56-1.68) | 0.93 |
Age | < 60 | 191 | 206 | 1.15 (0.83-1.59) | 0.40 | 1.04 (0.68-1.58) | 1.60 (0.70-3.69) | 0.54 |
60+ | 200 | 252 | 0.82 (0.60-1.10) | 0.19 | 0.87 (0.58-1.28) | 0.60 (0.28-1.28) | 0.38 | |
BMI | ≤ 26.2 | 164 | 226 | 1.00 (0.72-1.39) | 1.00 | 0.96 (0.62-1.47) | 1.08 (0.47-2.44) | 0.96 |
> 26.2 | 211 | 203 | 0.94 (0.69-1.30) | 0.74 | 0.98 (0.65-1.49) | 0.84 (0.38-1.84) | 0.91 | |
Family | No | 329 | 403 | 0.93 (0.74-1.18) | 0.58 | 1.01 (0.74-1.37) | 0.77 (0.43-1.38) | 0.66 |
history | Yes | 50 | 32 | 2.18 (0.89-5.34) | 0.09 | 1.20 (0.40-3.61) | 21.1 (1.34-334) | 0.09 |
Stage | 1 | 103 | 458 | 1.00 (0.70-1.41) | 0.99 | 0.95 (0.60-1.50) | 1.08 (0.44-2.63) | 0.96 |
2 | 29 | 458 | 1.24 (0.65-2.35) | 0.51 | 1.09 (0.49-2.41) | 2.25 (0.28-17.8) | 0.74 | |
3 | 196 | 458 | 0.86 (0.66-1.13) | 0.28 | 0.82 (0.58-1.18) | 0.80 (0.41-1.56) | 0.52 | |
4 | 55 | 458 | 1.26 (0.78-2.02) | 0.35 | 1.54 (0.82-2.89) | 1.07 (0.35-3.26) | 0.40 | |
Grade | 0 | 64 | 458 | 1.26 (0.80-1.99) | 0.32 | 1.12 (0.64-1.95) | 2.34 (0.52-10.4) | 0.52 |
1 | 12 | 458 | 0.37 (0.16-0.88) | 0.02 | 0.19 (0.04-0.94) | 0.15 (0.02-1.11) | 0.09 | |
2 | 41 | 458 | 0.88 (0.53-1.46) | 0.62 | 1.09 (0.54-2.23) | 0.61 (0.21-1.81) | 0.60 | |
3 | 146 | 458 | 0.99 (0.73-1.35) | 0.94 | 0.97 (0.65-1.44) | 1.02 (0.46-2.27) | 0.98 | |
4 | 121 | 458 | 0.93 (0.68-1.29) | 0.68 | 0.93 (0.60-1.42) | 0.89 (0.40-1.98) | 0.92 | |
Histology | Serous | 232 | 458 | 0.93 (0.72-1.21) | 0.60 | 0.87 (0.62-1.21) | 1.00 (0.52-1.93) | 0.70 |
Mucinous | 27 | 458 | 1.24 (0.63-2.44) | 0.53 | 0.89 (0.40-1.97) | n.a. | 0.96 | |
Endometriod | 64 | 458 | 0.94 (0.62-1.41) | 0.76 | 1.55 (0.84-2.86) | 0.53 (0.23-1.22) | 0.07 | |
Clear cell | 25 | 458 | 1.04 (0.54-2.00) | 0.91 | 0.81 (0.35-1.90) | 1.91 (0.23-15.7) | 0.70 | |
Mixed cell | 32 | 458 | 1.42 (0.76-2.68) | 0.27 | 1.30 (0.60-2.80) | 2.73 (0.35-21.4) | 0.55 | |
Behavior | Malignant | 327 | 458 | 0.93 (0.74-1.17) | 0.52 | 0.92 (0.68-1.25) | 0.87 (0.49-1.53) | 0.81 |
Borderline | 64 | 458 | 1.20 (0.76-1.88) | 0.43 | 1.03 (0.59-1.80) | 2.29 (0.52-10.2) | 0.55 | |