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Table 2 TCF7L2 rs12255372 and risk of ovarian cancer

From: No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer

   N N Ordinal OR (95% CI) Co-Dominant ORs (95% CI)
   Cases Controls Per T-allele P (trend) GT v GG TT v GG P (2 d.f.)
Total --- 391 458 0.96 (0.77-1.20) 0.75 0.95 (0.71-1.26) 0.97 (0.56-1.68) 0.93
Age < 60 191 206 1.15 (0.83-1.59) 0.40 1.04 (0.68-1.58) 1.60 (0.70-3.69) 0.54
  60+ 200 252 0.82 (0.60-1.10) 0.19 0.87 (0.58-1.28) 0.60 (0.28-1.28) 0.38
BMI ≤ 26.2 164 226 1.00 (0.72-1.39) 1.00 0.96 (0.62-1.47) 1.08 (0.47-2.44) 0.96
  > 26.2 211 203 0.94 (0.69-1.30) 0.74 0.98 (0.65-1.49) 0.84 (0.38-1.84) 0.91
Family No 329 403 0.93 (0.74-1.18) 0.58 1.01 (0.74-1.37) 0.77 (0.43-1.38) 0.66
history Yes 50 32 2.18 (0.89-5.34) 0.09 1.20 (0.40-3.61) 21.1 (1.34-334) 0.09
Stage 1 103 458 1.00 (0.70-1.41) 0.99 0.95 (0.60-1.50) 1.08 (0.44-2.63) 0.96
  2 29 458 1.24 (0.65-2.35) 0.51 1.09 (0.49-2.41) 2.25 (0.28-17.8) 0.74
  3 196 458 0.86 (0.66-1.13) 0.28 0.82 (0.58-1.18) 0.80 (0.41-1.56) 0.52
  4 55 458 1.26 (0.78-2.02) 0.35 1.54 (0.82-2.89) 1.07 (0.35-3.26) 0.40
Grade 0 64 458 1.26 (0.80-1.99) 0.32 1.12 (0.64-1.95) 2.34 (0.52-10.4) 0.52
  1 12 458 0.37 (0.16-0.88) 0.02 0.19 (0.04-0.94) 0.15 (0.02-1.11) 0.09
  2 41 458 0.88 (0.53-1.46) 0.62 1.09 (0.54-2.23) 0.61 (0.21-1.81) 0.60
  3 146 458 0.99 (0.73-1.35) 0.94 0.97 (0.65-1.44) 1.02 (0.46-2.27) 0.98
  4 121 458 0.93 (0.68-1.29) 0.68 0.93 (0.60-1.42) 0.89 (0.40-1.98) 0.92
Histology Serous 232 458 0.93 (0.72-1.21) 0.60 0.87 (0.62-1.21) 1.00 (0.52-1.93) 0.70
  Mucinous 27 458 1.24 (0.63-2.44) 0.53 0.89 (0.40-1.97) n.a. 0.96
  Endometriod 64 458 0.94 (0.62-1.41) 0.76 1.55 (0.84-2.86) 0.53 (0.23-1.22) 0.07
  Clear cell 25 458 1.04 (0.54-2.00) 0.91 0.81 (0.35-1.90) 1.91 (0.23-15.7) 0.70
  Mixed cell 32 458 1.42 (0.76-2.68) 0.27 1.30 (0.60-2.80) 2.73 (0.35-21.4) 0.55
Behavior Malignant 327 458 0.93 (0.74-1.17) 0.52 0.92 (0.68-1.25) 0.87 (0.49-1.53) 0.81
  Borderline 64 458 1.20 (0.76-1.88) 0.43 1.03 (0.59-1.80) 2.29 (0.52-10.2) 0.55
  1. BMI, body mass index, categorized by median value; family history, first-degree or second-degree family history; analyses adjusted for age (unless used as stratifiying variable) and region of residence; n.a., not estimatable, bold indicates p < 0.05.