Skip to main content

Table 1 TCF7L2 rs12255372 and risk of breast cancer

From: No association between a candidate TCF7L2 variant and risk of breast or ovarian cancer

   N N Ordinal OR (95% CI) Co-Dominant ORs (95% CI)
   Cases Controls Per T-allele P (trend) GT v GG TT v GG P (2 d.f.)
Total --- 779 830 1.04 (0.89-1.22) 0.62 1.16 (0.93-1.43) 0.92 (0.62-1.36) 0.31
Menopausal Pre 268 213 1.28 (0.94-1.75) 0.12 1.51 (1.01-2.26) 1.21 (0.56-2.61) 0.14
status Post 467 573 0.95 (0.77-1.16) 0.59 1.03 (0.78-1.34) 0.79 (0.49-1.29) 0.60
BMI ≤ 25.9 341 394 1.07 (0.84-1.37) 0.59 1.25 (0.90-1.73) 0.91 (0.50-1.64) 0.34
  > 25.9 406 393 1.03 (0.82-1.30) 0.78 1.13 (0.83-1.54) 0.92 (0.52-1.63) 0.66
Family No 424 480 1.04 (0.84-1.30) 0.70 1.09 (0.81-1.46) 1.02 (0.60-1.73) 0.85
history Yes 336 312 0.99 (0.77-1.28) 0.95 1.25 (0.89-1.76) 0.68 (0.36-1.28) 0.14
Estrogen Positive 472 830 1.09 (0.91-1.31) 0.34 1.16 (0.90-1.49) 1.10 (0.70-1.71) 0.50
Receptor (ER) Negative 107 830 1.11 (0.81-1.52) 0.52 1.41 (0.92-2.17) 0.84 (0.36-1.96) 0.21
Progesterone Positive 429 830 1.21 (0.93-1.35) 0.23 1.19 (0.92-1.54) 1.15 (0.73-1.81) 0.39
Receptor (PR) Negative 147 830 1.00 (0.76-1.32) 0.99 1.19 (0.82-1.71) 0.74 (0.35-1.56) 0.40
HER2 status Positive 122 830 1.14 (0.83-1.55) 0.42 1.68 (1.12-2.53) 0.49 (0.17-1.45) 0.01
  Negative 269 830 1.02 (0.82-1.27) 0.85 1.04 (0.78-1.40) 1.01 (0.60-1.70) 0.96
ER, PR, HER2 All Negative 51 842 1.47 (0.95-2.26) 0.08 2.16 (1.16-4.01) 1.36 (0.43-4.30) 0.05
  1. BMI, body mass index, categorized by median value; family history, first-degree or second-degree family history; analyses adjusted for age, region of residence, oral contraceptive use, hormone therapy use, age at first birth, age at menarche, menopausal status (unless used as stratifiying variable), and pack years of smoking; n.a., not estimatable, bold indicates p < 0.05.