Table 2 Distribution of protein expression of the apoptotic and antiapoptotic markers, Cox proportional hazard ratios (HR) and 95% confidence intervals (CI) for overall survival by the biomarker status for ESCC patients.
From: Biomarkers of apoptosis and survival in esophageal squamous cell carcinoma
| Gene protein | N1 | Distribution of protein expression by overall score (N, prevalence)2 |
HR3
(95% CI) P-value | Number (prevalence) with positive protein expression score4 |
HR5
(95% CI) P-value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Score | |||||||||||||
| 0 | 1 | 2 | 3 | 4 | 6 | 8 | 9 | 12 | |||||
| FasL | 244 |
15 (0.06) |
48 (0.20) |
92 (0.38) |
80 (0.33) |
3 (0.01) |
6 (0.03) | --- | --- | --- |
1.10 (0.95-1.27) 0.45 | 9 (0.04) |
1.04 (0.45-2.40) 0.92 |
| Fas | 244 |
24 (0.10) |
49 (0.20) |
44 (0.18) |
91 (0.37) |
8 (0.03) |
22 (0.09) | --- |
5 (0.02) |
1 (0.00) |
0.95 (0.87-1.04) 0.07 | 36 (0.15) |
0.79 (0.49-1.27) 0.32 |
| FADD | 248 |
10 (0.04) |
122 (0.49) |
72 (0.29) |
8 (0.03) |
17 (0.07) |
12 (0.05) |
4 (0.02) |
1 (0.00) |
2 (0.01) |
1.05 (0.96-1.14) 0.79 | 36 (0.15) |
1.22 (0.77-1.92) 0.39 |
| pFADD | 247 |
190 (0.77) |
48 (0.19) |
9 (0.04) | --- | --- | --- | --- | --- | --- |
1.02 (0.76-1.38) 0.25 | 0 (0.00) | --- |
| Caspase 8 | 244 |
11 (0.05) |
76 (0.31) |
144 (0.59) | --- |
11 (0.05) |
2 (0.01) | --- | --- | --- |
0.92 (0.76-1.11) 0.53 | 13 (0.05) |
1.03 (0.51-2.05) 0.94 |
| Caspase 10 | 235 |
6 (0.03) |
47 (0.20) |
161 (0.69) | --- |
17 (0.07) |
3 (0.01) | --- |
1 (0.00) | --- |
1.07 (0.93-1.23) 0.46 | 21 (0.09) |
1.36 (0.81-2.27) 0.25 |
| Bcl2 | 253 |
23 (0.09) |
167 (0.66) |
58 (0.23) | --- |
5 (0.02) | --- | --- | --- | --- |
1.01 (0.81-1.27) 0.63 | 5 (0.02) |
1.29 (0.52-3.25) 0.58 |