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Table 2 Distribution of protein expression of the apoptotic and antiapoptotic markers, Cox proportional hazard ratios (HR) and 95% confidence intervals (CI) for overall survival by the biomarker status for ESCC patients.

From: Biomarkers of apoptosis and survival in esophageal squamous cell carcinoma

Gene protein N1 Distribution of protein expression by overall score (N, prevalence)2 HR3
(95% CI)
P-value
Number (prevalence) with positive protein expression score4 HR5
(95% CI)
P-value
   Score    
   0 1 2 3 4 6 8 9 12    
FasL 244 15
(0.06)
48
(0.20)
92
(0.38)
80
(0.33)
3
(0.01)
6
(0.03)
--- --- --- 1.10
(0.95-1.27)
0.45
9 (0.04) 1.04
(0.45-2.40)
0.92
Fas 244 24
(0.10)
49
(0.20)
44
(0.18)
91
(0.37)
8
(0.03)
22
(0.09)
--- 5
(0.02)
1
(0.00)
0.95
(0.87-1.04)
0.07
36 (0.15) 0.79
(0.49-1.27)
0.32
FADD 248 10
(0.04)
122
(0.49)
72
(0.29)
8
(0.03)
17
(0.07)
12
(0.05)
4
(0.02)
1
(0.00)
2
(0.01)
1.05
(0.96-1.14)
0.79
36 (0.15) 1.22
(0.77-1.92)
0.39
pFADD 247 190
(0.77)
48
(0.19)
9
(0.04)
--- --- --- --- --- --- 1.02
(0.76-1.38)
0.25
0 (0.00) ---
Caspase 8 244 11
(0.05)
76
(0.31)
144
(0.59)
--- 11
(0.05)
2
(0.01)
--- --- --- 0.92
(0.76-1.11)
0.53
13 (0.05) 1.03
(0.51-2.05)
0.94
Caspase 10 235 6
(0.03)
47
(0.20)
161
(0.69)
--- 17
(0.07)
3
(0.01)
--- 1
(0.00)
--- 1.07
(0.93-1.23)
0.46
21 (0.09) 1.36
(0.81-2.27)
0.25
Bcl2 253 23
(0.09)
167
(0.66)
58
(0.23)
--- 5
(0.02)
--- --- --- --- 1.01
(0.81-1.27)
0.63
5 (0.02) 1.29
(0.52-3.25)
0.58
  1. 1N shown is for each individual biomarker and is less than 265 total because none of 7 biomarkers had data for all 265 ESCC cases.
  2. 2Overall score calculated as (intensity score) times (percent cells positive score) as described in methods.
  3. 3HR = hazard ratio (95% confidence interval) for increase in score of one category; from multivariate Cox proportional hazards model, adjusted for gender, age, tobacco use, alcohol use, family history of UGI cancer, tumor grade, tumor stage, metastasis, and degree differentiation.
  4. 4Positive protein expression = overall score ≥ 4 (negative = overall score ≤ 3).
  5. 5HR = hazard ratio (95% confidence interval) for positive protein expression (versus negative); from multivariate Cox proportional hazards model, adjusted for gender, age, tobacco use, alcohol use, family history of UGI cancer, tumor grade, tumor stage, metastasis, and degree differentiation.