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Table 2 Biomarker protein expressions in the prostate lobes of 12 week old non-transgenic and SV-40 Tag rats

From: Characterization of SV-40 Tag rats as a model to study prostate cancer

  Non-transgenic Ventral Prostate SV-40 Tag Ventral Prostate Non-transgenic Dorsolateral Prostate SV-40 Tag Dorsolateral Prostate
Androgen Receptor 100 ± 12 185 ± 22* 100 ± 7 116 ± 11
Estrogen Receptor-alpha 100 ± 6 49 ± 7* 100 ± 9 51 ± 7*
Insulin-like Growth Factor-1 100 ± 3 110 ± 4* 100 ± 2 146 ± 6*
Insulin-like Growth Factor-1-alpha Receptor 100 ± 3 253 ± 32* 100 ± 6 138 ± 3*
Total-Extracellular Regulating Kinase-1 100 ± 5 302 ± 64* 100 ± 19 174 ± 21*
Total-Extracellular Regulating Kinase-2 100 ± 4 298 ± 58** 100 ± 16 157 ± 16*
  1. Protein expressions were determined by immunoblot analysis, except for IGF-1 levels that were determined by ELISA (n = 6 per group). Protein expressions for non-transgenic rats were set to 100 and those of transgenic rats are presented as percent of non-transgenic rats ± SEM. *P < 0.05 and **P < 0.01 compared to non-transgenic rats by two-tailed Students t test.