Plexin D1 is ubiquitously expressed on tumor vessels and tumor cells in solid malignancies

BMC Cancer

Table 1 Plexin D1 expression in solid malignancies.

Malignant tissue	PLXND1 expression				Remarks
	Endothelial cells	Tumor cells	Subset of macrophages	Subset of fibroblasts
*Paired samples*
Medullary breast carcinoma (n = 1)	-	-	+	+	Plasma cells also positive
Lymph node metastasis (n = 1)	Subset	-	+	n.d.
Ductal breast carcinoma (n = 8)	+	+	+	+	Some plasma cells also positive
Lymph node metastasis (n = 8)	+	+	+	+
Adenocarcinoma of colon (n = 4)	+	+	+	+
Liver metastasis (n = 4)	+	+	+	+
Alveolar soft part sarcoma of femur (n = 1)	+	+	n.d.	n.d.
Brain metastasis (n = 1)	+	+	n.d.	n.d.
Renal cell carcinoma (n = 1)	+	+	n.d.	n.d.
Brain metastasis (n = 1)	+	+	n.d.	n.d.
*Non-paired samples*
Adenocarcinoma of coecum (n = 1)	+	+	+	-
Adenocarcinoma of oesophagus (n = 1)	+	+	+	-
Adenocarcinoma of ovary (n = 1)	Subset	+	+	+
Adenocarcinoma of prostate (n = 1)	+	+	-	-
Adenocarcinoma of rectum (n = 5)	+	+	+	+
Brain metastasis of adenocarcinoma (n = 4)	+	+	n.d.	n.d.
Liver metastasis of adenocarcinoma colon (n = 8)	+	+	+	+
Ovary metastasis of adenocarcinoma colon (n = 1)	-	+	-	-
Low grade astrocytoma (n = 2)	Subset	Subset	n.d.	n.d.
Glioblastoma Multiforme (n = 3)	+	+	n.d.	n.d.
Medulloblastoma (n = 1)	+	+	n.d.	n.d.
Neuro-endocrine tumor of lung (n = 2)	+	+	+	n.d.
Medullary breast carcinoma of (n = 4)	+	+	+	+	2 samples negative vessels and tumor cells
Lymph node metastasis of ductal breast carcinoma (n = 1)	Subset	+	-	-
Squamous cell carcinoma of cervix (n = 5)	Subset	+	+	-	1 sample negative vessels and tumor cells
Squamous cell carcinoma of vulva (n = 5)	-	-	+	+
Urothelial cell carcinoma of prostate (n = 2)	+	+	+	-

ISSN: 1471-2407