Figure 2
From: Plexin D1 is ubiquitously expressed on tumor vessels and tumor cells in solid malignancies
PLXND1 expression in representative clinical (tumor) samples. Immunohistochemical analyses using a single domain antibody against PLXND1 (Magnification ×200). PLXND1 is expressed at high levels in primary ductal breast carcinomas (A) and corresponding lymph node metastases (B), colon adenocarcinomas (C) and corresponding liver metastases (D) and a renal cell carcinoma (E) and corresponding brain metastasis (F). The arrows point at PLXND1-expressing tumor vessels. PLXND1 is not detected in normal human cerebral cortex (G) and heart (H) tissue samples. The insets in F, G and H show corresponding PLXND1 mRNA in situ hybridization analyses (Magnification ×200).