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Table 2 Median, range and mean labeling index for different immune cells (CD3+, CD8+, CD20+, CD68+, FoxP3+, Granzyme B+) within primary tumor, metastatic lymph nodes and uninvolved regional lymph nodes

From: Distribution of immune cells in head and neck cancer: CD8+ T-cells and CD20+B-cells in metastatic lymph nodes are associated with favourable outcome in patients with oro- and hypopharyngeal carcinoma

TIL   Primary-
tumor
Intraepithelial N+ node Peritumoral N+ node Non-metastatic node
   cells per 100 tumor cells cells per image (0.087 mm2)
CD3      
  Median (range) 3.04
(0–19)
3.52
(0.16–13.52)
204.5
(60–341)
183
(54–348)
  Mean ± SE 4.36 ± 4.92 4.34 ± 4.64 209.1 ± 68.5 183.4 ± 69.3
CD8      
  Median (range) 2.49
(0.19–17.79)
1.29
(0.16–16.23)
37.5
(10–149)
88
(25–308)
  Mean ± SE 3.54 ± 4.48 3.31 ± 4.71 45.8 ± 37.5 108.5 ± 69.8
CD20      
  Median (range) 0.23
(0.11–5.26)
1.76
(0.15–5.22)
192
(19–631)
148.5
(14–321)
  Mean ± SE 0.91 ± 1.48 2.53 ± 2.93 200.6 ± 124.3 148.9 ± 83.9
CD68      
  Median (range) 1.02
(0.15–5.22)
1.05
(0–4.93)
5.5
(1–17)
4
(1–23)
  Mean ± SE 1.17 ± 1.26 1.37 ± 1.26 6.5 ± 4.7 7 ± 6.2
FoxP3      
  Median (range) 1.81
(0.15–13.0)
2.26
(0.32–18.4)
44
(4–134)
49.5
(10–139)
  Mean ± SE 2.88 ± 2.90 2.96 ± 3.29 49.0 ± 33.2 53.6 ± 26.4
Granzyme B      
  Median (range) 1
(0–21)
0
(0–10)
0
(0–54)
3
(0–39)
  Mean ± SE 2.03 ± 3.93 1.39 ± 2.70 4.79 ± 11.52 5.27 ± 7.96