Table 2 Median, range and mean labeling index for different immune cells (CD3+, CD8+, CD20+, CD68+, FoxP3+, Granzyme B+) within primary tumor, metastatic lymph nodes and uninvolved regional lymph nodes

CD3

Median (range)

3.04

(0–19)

3.52

(0.16–13.52)

204.5

(60–341)

183

(54–348)

Mean ± SE

4.36 ± 4.92

4.34 ± 4.64

209.1 ± 68.5

183.4 ± 69.3

CD8

Median (range)

2.49

(0.19–17.79)

1.29

(0.16–16.23)

37.5

(10–149)

88

(25–308)

Mean ± SE

3.54 ± 4.48

3.31 ± 4.71

45.8 ± 37.5

108.5 ± 69.8

CD20

Median (range)

0.23

(0.11–5.26)

1.76

(0.15–5.22)

192

(19–631)

148.5

(14–321)

Mean ± SE

0.91 ± 1.48

2.53 ± 2.93

200.6 ± 124.3

148.9 ± 83.9

CD68

Median (range)

1.02

(0.15–5.22)

1.05

(0–4.93)

5.5

(1–17)

4

(1–23)

Mean ± SE

1.17 ± 1.26

1.37 ± 1.26

6.5 ± 4.7

7 ± 6.2

FoxP3

Median (range)

1.81

(0.15–13.0)

2.26

(0.32–18.4)

44

(4–134)

49.5

(10–139)

Mean ± SE

2.88 ± 2.90

2.96 ± 3.29

49.0 ± 33.2

53.6 ± 26.4

Granzyme B

Median (range)

1

(0–21)

0

(0–10)

0

(0–54)

3

(0–39)

Mean ± SE

2.03 ± 3.93

1.39 ± 2.70

4.79 ± 11.52

5.27 ± 7.96