Citrus auraptene suppresses cyclin D1 and significantly delays N-methyl nitrosourea induced mammary carcinogenesis in female Sprague-Dawley rats

Table 1 Summary of the effects of auraptene on rat mammary tumorigenesis

Group	Treatment	Incidence^a	Multiplicity^a	Median time to tumor (days)
112 days (16 weeks)
2	MNU + Teklad (control)	84.6 ± 7.2	1.92 ± 0.27
3	MNU + Aur. 200	76.9 ± 8.4	1.69 ± 0.27
4	MNU + Aur. 500	45.8 ± 10.4^b	1.21 ± 0.35^c
126 days (18 weeks)
2	MNU + Teklad (control)	80.7 ± 7.8	2.50 ± 0.34	80
3	MNU + Aur. 200	80.7 ± 7.8	2.08 ± 0.33	92
4	MNU + Aur. 500	66.7 ± 9.8	2.00 ± 0.43	119^d

^a Figures represent means ± SE. ^bStatistically significant (p ≤ 0.05) using ANOVA followed by Tukey test. ^cStatistically significant (p ≤ 0.05) using Mann-Whitney U-test. ^dStatistically significant (p ≤ 0.05) using the log-rank test.

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