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Table 4 Comparison of individual and overall (random-effects) estimates for the two reviews – pancreatic cancer

From: The relation between smokeless tobacco and cancer in Northern Europe and North America. A commentary on differences between the conclusions reached by two recent reviews

 

ST usea

     

Ref

Type

Exposure

Inclusion of smokersb

Reviewc

Sex

Relative risk (95% CI)

Comments

[26]

ST

Ever

SNS

L&H

M

1.7 (0.9–3.1)

 
 

ST

Ever

SNS

B

M

1.7 (0.9–3.1)

Estimates agree

[4]

Snuff

Ever

SNS

L&H

M

1.67 (1.12–2.50)

Estimates for NS also available

 

Snuff

Ever

SNS

B

M

1.7 (1.1–2.5)

Estimates agreed

[5]

Snuff

Ever

SNS

L&H

M

0.9 (0.7–1.2)

 
 

Snuff

Ever

NS

B

M

2.0 (1.2–3.3)

NS not SNS

[27]

ST

Ever

SNS

L&H

M

0.29 (0.09–0.92)e

Not included by B

[28]

Chew

Ever

NS

L&H

M

2.82 (0.85–9.39)

Personal communication from Dr Muscat

 

Chew

Ever

NSf

B

M

3.6 (1.0–12.8)

Estimate actually for non-current smokers

[29]

ST

Ever

NSg

L&H

M+F

1.1 (0.4–3.1)

 
 

ST

Ever

NS

B

M+F

1.4 (0.5–3.6)

Estimate biased as pipe and cigar smokers included in numerator only

[30]

ST

Ever

SNS

L&H

M+F

0.65 (0.43–0.97)e

Estimate for NS also available

 

Chew

Ever

NS

B

M+F

0.6 (0.3–1.4)

Chew not ST; NS not SNS

Total

   

L&H

 

1.07 (0.71–1.60)

7 estimates

    

B

 

1.6 (1.1–2.2)

6 estimates

  1. a ST = smokeless tobacco; ever exposure includes undefined use.
  2. b NS = never smokers; SNS = smokers and nonsmokers combined (with adjustment for smoking).
  3. c L&H = Lee and Hamling review [2]; B = Boffetta et al. review [1].
  4. d To within rounding error, as B only expressed estimates to one decimal place.
  5. e Estimated from data provided.
  6. f See comment.
  7. g Never cigarette smokers, with adjustment for other tobacco use.