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Figure 4 | BMC Cancer

Figure 4

From: Cyclophilin C-associated protein (CyCAP) knock-out mice spontaneously develop colonic mucosal hyperplasia and exaggerated tumorigenesis after treatment with carcinogen azoxymethane1

Figure 4

The differences in the crypt length and crypt cell content are more obvious between WT and KO animals after the treatment by azoxymethane. After the treatment by azoxymethane, the CyCAP-/- mice develop more extensive mucosal hyperplasia of the colon than WT animals (p < 0.0001, T-test). The mononuclear inflammatory content in the lamina propria is not increased compared to WT animals (20 × magnification, H&E).

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BMC Cancer

ISSN: 1471-2407

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