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Table 1 Clinicopathological characteristics and tumor biomarker score according to microsatellite status.

From: Microsatellite instability in colorectal cancer and association with thymidylate synthase and dihydropyrimidine dehydrogenase expression

  MSI*
n = 43
MSS*
n = 268
P
  No. (%) No. (%)  
Gender      
   Male 21 (49) 138 (51) 0.9
   Female 22 (51) 130 (49)  
Age      
   <70 28 (65) 217 (81) 0.02
   ≥70 15 (35) 51 (19)  
Tumor site      
   Proximal colon 36 (84) 68 (25) 0.001
   Distal colon 6 (14) 145 (54)  
   Rectum 1 (2) 55 (21)  
Stage      
   II 6 (14) 26 (10) 0.4
   III 34 (79) 210 (78)  
   IV 3 (7) 32 (12)  
Differentiation grade (WHO)      
   Well 5 (12) 88 (33) 0.001
   Intermediate 7 (16) 121 (45)  
   Poor 31 (72) 59 (22)  
Perineural tumor invasion      
   + 5 (12) 53 (20) 0.5
   - 19 (44) 137 (51)  
   not assessed 19 (44) 78 (29)  
Vascular tumor invasion      
   V0 18 (42) 142 (53) 0.8
   V1 8 (19) 58 (22)  
   Vx 17 (39) 68 (25)  
Intestinal perforation at resection      
   yes 2 (5) 29 (11) 0.2
   no 41 (95) 239 (89)  
Bowel obstruction before resection      
   yes 1 (2) 44 (16) 0.01
   no 42 (98) 224 (84)  
Thymidylate synthase level      
   Low 12 (28) 218 (81) 0.001
   High 30 (70) 47 (18)  
   not assessed 1 (2) 3 (1)  
Dihydropyrimidine dehydrogenase level      
   Low 21 (49) 163 (61) 0.1
   High 21 (49) 97 (36)  
   not assessed 1 (2) 8 (3)  
  1. *instable (MSI) or stable (MSS) microsatellites