Table 1 Clinicopathological characteristics and tumor biomarker score according to microsatellite status.
MSI* n = 43 | MSS* n = 268 | P | |||
|---|---|---|---|---|---|
No. | (%) | No. | (%) | ||
Gender | |||||
Male | 21 | (49) | 138 | (51) | 0.9 |
Female | 22 | (51) | 130 | (49) | |
Age | |||||
<70 | 28 | (65) | 217 | (81) | 0.02 |
≥70 | 15 | (35) | 51 | (19) | |
Tumor site | |||||
Proximal colon | 36 | (84) | 68 | (25) | 0.001 |
Distal colon | 6 | (14) | 145 | (54) | |
Rectum | 1 | (2) | 55 | (21) | |
Stage | |||||
II | 6 | (14) | 26 | (10) | 0.4 |
III | 34 | (79) | 210 | (78) | |
IV | 3 | (7) | 32 | (12) | |
Differentiation grade (WHO) | |||||
Well | 5 | (12) | 88 | (33) | 0.001 |
Intermediate | 7 | (16) | 121 | (45) | |
Poor | 31 | (72) | 59 | (22) | |
Perineural tumor invasion | |||||
+ | 5 | (12) | 53 | (20) | 0.5 |
- | 19 | (44) | 137 | (51) | |
not assessed | 19 | (44) | 78 | (29) | |
Vascular tumor invasion | |||||
V0 | 18 | (42) | 142 | (53) | 0.8 |
V1 | 8 | (19) | 58 | (22) | |
Vx | 17 | (39) | 68 | (25) | |
Intestinal perforation at resection | |||||
yes | 2 | (5) | 29 | (11) | 0.2 |
no | 41 | (95) | 239 | (89) | |
Bowel obstruction before resection | |||||
yes | 1 | (2) | 44 | (16) | 0.01 |
no | 42 | (98) | 224 | (84) | |
Thymidylate synthase level | |||||
Low | 12 | (28) | 218 | (81) | 0.001 |
High | 30 | (70) | 47 | (18) | |
not assessed | 1 | (2) | 3 | (1) | |
Dihydropyrimidine dehydrogenase level | |||||
Low | 21 | (49) | 163 | (61) | 0.1 |
High | 21 | (49) | 97 | (36) | |
not assessed | 1 | (2) | 8 | (3) | |