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Table 2 Cumulative incidence of toxicities

From: Efficacy of sorafenib on metastatic renal cell carcinoma in Asian patients: Results from a multicenter study

  Toxicity grade
  Sorafenib as First Line Treatment
(N = 59)
Sorafenib as Second Line Treatment
(N = 39)
Toxicity 1–2 3–4 1–2 3–4
Hand-foot syndrome 44 8 21 5
Alopecia 41 1 25 0
Rash 22 0 11 0
Mucositis (oral cavity) 11 1 5 0
Diarrhea 25 1 16 0
Hypertension 14 1 7 1
Fatigue & Anepithymia 41 1 30 2
Weight loss 6 0 3 0
Hemorrhage (nasal     
mucocutaneous) 6 0 3 0
Anemia 7 1 5 0
Thrombocytopenia 0 0 1 0
Leukopenia 0 0 0 0
Hemorrhage (digestive tract) 0 1 1 2
Hematuria 4 0 0 0
Hemoptysis 8 1 4 1
Liver dysfunction 7 2 3 0
Angina 0 1 0 0