From: A novel chalcone derivative which acts as a microtubule depolymerising agent and an inhibitor of P-gp and BCRP in in-vitro and in-vivoglioblastoma models
Cell line
U118
U138
U373
LN229
GL26
Caspase-3 activity (A.U.)
13 ± 3*
6 ± 2
39 ± 3*
120 ± 25*
ND
Hypodiploid cells (%)
26 ± 10*
17 ± 1*
20 ± 2*
30 ± 5*
25 ± 5*
Apoptotic+necrotic cells (%)
21 ± 5*
20 ± 3*
34 ± 2*
31 ± 2*
25 ± 8*