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Figure 4 | BMC Cancer

Figure 4

From: Staurosporine augments EGF-mediated EMT in PMC42-LA cells through actin depolymerisation, focal contact size reduction and Snail1 induction – A model for cross-modulation

Figure 4

QRT-PCR of PMC42-LA cells treated for 72 h with 10 ng/ml EGF, 40 nM ST or both. Control: untreated (A) E-cadherin mRNA expression plotted against increased expression of hallmark mesenchymal genes MMP-2 and vimentin. (B) Comparison of expression of four E-cadherin repressor genes in the treatment regime used in A. Error bar values are standard error. Significance was set at p </= 0.05. * symbol indicates a statistically significant difference from the control within each time point. In the combined treatment, ^ and # indicate statistical significance from ST and EGF individual treatments, respectively, within each time point.

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BMC Cancer

ISSN: 1471-2407

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