Table 2 Individual local tumor response.
Macroscopic tumor response | Patient | Initial tumor size (% tumor of intestinal lumen) | after 3–4 months of therapy | best response | |
|---|---|---|---|---|---|
Complete luminal response of the primary (group I) | Normal mucosa (Ia) | Pat. 07 | 85% | 30% | 30% |
Pat. 09 | 85% | 0% | 0% | ||
death | related to metastasis | n = 1 | 0 alive | ||
related to other causes | n = 1 | ||||
Adenomatous tissue (Ib) | Pat. 05* | 85% | 70% | 30% | |
Pat. 10* | R: 85%/L: 50% | R: 60%/L: | R: 60%/L: OP | ||
Pat. 12 | 85% | 30% | 5% | ||
Pat. 15* | 95% | 20% | 40% | ||
85% | |||||
death | related to metastasis | n = 3 | 0 alive | ||
related to other causes | n = 1 | ||||
Relapse after therapeutic break (group II) | Initially no tumor cells at biopsy | Pat. 03 | 80% | 60% | 0% |
Pat. 06* | 85% | 30% | 30% | ||
Pat. 08* | 100% | 85% | 55% | ||
Pat. 20* | 75% | 25% | 25% | ||
death | related to metastasis | n = 1 | 3 alive | ||
related to other causes | n = 0 | ||||
Partial macros-copic response of the primary (group III) | Histologically confirmed tumor tissue | Pat. 01* | 85% | 85% | 85% |
Pat. 02* | 90% | 85% | 70% | ||
Pat. 04* | 85% | 80% | 80% | ||
Pat. 11* | 85% | 75% | 75% | ||
Pat. 13* | 100% | 85% | 85% | ||
Pat. 14 | 60% | 40% | OP | ||
Pat. 16* | 60% | 30% | 20% | ||
Pat. 17* | 100% | 85% | 85% | ||
Pat. 18* | 90% | 85% | 85% | ||
Pat. 19* | 80% | 70% | 65% | ||
death | related to metastasis | n = 8 | 2 alive | ||
related to other causes | n = 0 | ||||