Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer

Table 5 Multivariate Cox regression analysis of DKK3 promoter methylation with regard to disease-free survival

			Multivariate analysis Disease-free survival (global model)			Multivariate analysis Disease-free survival (reverse selection procedure²)
Variable			HR	95% CI¹	P	HR	95% CI¹	P
Age at diagnosis	<57 years	0	1.0
	≥ 57 years	1	0.57	0.24 – 1.33	0.191
Tumor size	pT1-2	0	1.0
	pT3-4	1	0.61	0.22 – 1.72	0.353
Lymph nodes	pN0	0	1.0			1.0
	pN1-3	1	4.24	1.50 – 11.96	0.006	4.01	1.49 – 10.81	0.006
Histological grade	G1	0	1.0			1.0
	G2-G3	1	2.01	0.91 – 4.43	0.086	1.93	0.88 – 4.24	0.102
Histological type	IDC	0	1.0
	other	1	1.04	0.42–2.62	0.929
Estrogen receptor	negative	0	1.0
	positive	1	2.17	0.78 – 6.03	0.137
Progesterone receptor	negative	0	1.0			1.0
	positive	1	0.36	0.15 – 0.88	0.025	0.53	0.25 – 1.11	0.091
DKK3 promoter	unmethylated	0	1.0			1.0
	methylated	1	2.46	1.01 – 5.97	0.047	2.08	0.88 – 4.88	0.094

¹Confidence interval (CI) on the estimated hazard ratio (HR). ²Only terms that remained in the model after reverse selection are listed. All variables were stratified binary according to Table 3.

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