Figure 1From: A simple method for co-segregation analysis to evaluate the pathogenicity of unclassified variants; BRCA1 and BRCA2 as an example Illustration of our model. Hypothetical pedigree for the illustration of our model. Individuals are numbered 1–10 for identification and underneath the age at last contact is listed. Open circle: female, open square: male, closed circle: affected with breast (or ovarian) cancer at age × (BrCx). Unless specified by + (carrier of UV), - (no carrier), individuals are not genotyped. Proband is indicated by arrow.Back to article page