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Table 2 The cytotoxicity of DM4 and AVE9633 in K562, HL60 and their variant cell lines expressing P-gp in the presence or absence of the P-gp modulator Zosuquidar

From: P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients

IC50 HL60 HL60/DNR K562 K56/HHT40 K562/HHT90 K562/DOX
AVE9633 (nM) 19.9 ± 0.7 > 800     
AVE9633 + Zosuquidar 20.1 ± 1.1 10.4 ± 2.1     
DM4 (nM) 14.8 ± 0.3 > 800 11.8 ± 1.1 18.4 ± 1.2 36.6 ± 2.0 437.6 ± 15.1
DM4 + Zosuquidar 18.3 ± 1.3 10.9 ± 0.1 12.6 ± 1.2 6.5 ± 0.6 10.1 ± 0.8 11.6 ± 0.9
  1. * Zosuquidar: 0.3 μM