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Figure 6 | BMC Cancer

Figure 6

From: A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth

Figure 6

Amplification of KRAS in primary gastric cancer. (a) Quantitative PCR analysis of genomic DNA from primary gastric cancer specimens was carried out using primers specific for regions within and flanking the KRAS locus. DNA copy number relative to normal diploid leukocyte DNA is plotted onto the corresponding chromosomal nucleotide position in megabases. (b) KRAS is preferentially expressed in gastric cancer cells with KRAS amplification. Hematoxylin-Eosin staining (left) and immunohistochemical staining with an anti-KRAS antibody (right) of gastric cancer tissue (tumor D). Upper panels: poorly-differentiated adenocarcinoma cells with submucosal invasion. Lower panels: adenocarcinoma cells adjacent to normal pyloric glands.

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BMC Cancer

ISSN: 1471-2407

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