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Table 3 Marker expression and mammographic density stratified by total breast size

From: Mammographic density and epithelial histopathologic markers

Marker   Small total breast area Large total breast area
   Category*   Category  
   1 2 P-value 1 2 P-value
ERα % density 41.3 38.0 0.55 30.7 33.7 0.61
  Dense area# 29.5 29.1 0.92 34.6 39.7 0.53
  Number 63 16   59 19  
ERβ % density 41.3 39.5 0.71 29.9 36.3 0.24
  Dense area 28.9 29.7 0.82 34.1 41.2 0.34
  Number 50 29   60 18  
PR % density 39.0 43.3 0.36 27.1 33.3 0.19
  Dense area 28.8 29.8 0.78 28.3 40.0 0.05
  Number 45 36   32 45  
HER2/neu % density 41.7 39.8 0.71 30.4 33.5 0.51
  Dense area 30.3 28.6 0.65 35.2 37.6 0.71
  Number 55 24   49 28  
Ki-67 % density 38.2 42.6 0.35 29.7 30.9 0.81
  Dense area 25.4 31.8 0.07 35.8 34.5 0.85
  Number 30 49   35 41  
PCNA % density 41.0 39.9 0.81 29.9 33.9 0.43
  Dense area 29.4 28.8 0.86 33.7 40.5 0.32
  Number 43 38   52 25  
  1. * Categories for ERα, ERβ, HER2/neu and PCNA; category 1 <10% staining, category 2 ≥ 10% staining. Categories for PR and Ki-67; category 1 = no staining, category 2 = any staining
  2. Mean percent breast density
  3. # Mean dense area in cm2
  4. Mean values and p-values calculated using general linear models adjusted for age at mammogram, BMI, ethnicity, HT use at mammogram, menopausal status, parity, age at first live birth, age at menarche and family history of breast cancer.
  5. (ERα = estrogen receptor alpha; ERβ = estrogen receptor beta; PR = progesterone receptor; HER2/neu = Human Epidermal growth factor receptor2; PCNA = Proliferating Cell Nuclear Antigen; BMI = body mass index)