Skip to main content

Table 3 Marker expression and mammographic density stratified by total breast size

From: Mammographic density and epithelial histopathologic markers

Marker

 

Small total breast area

Large total breast area

  

Category*

 

Category

 
  

1

2

P-value

1

2

P-value

ERα

% density†

41.3

38.0

0.55

30.7

33.7

0.61

 

Dense area#

29.5

29.1

0.92

34.6

39.7

0.53

 

Number

63

16

 

59

19

 

ERβ

% density

41.3

39.5

0.71

29.9

36.3

0.24

 

Dense area

28.9

29.7

0.82

34.1

41.2

0.34

 

Number

50

29

 

60

18

 

PR

% density

39.0

43.3

0.36

27.1

33.3

0.19

 

Dense area

28.8

29.8

0.78

28.3

40.0

0.05

 

Number

45

36

 

32

45

 

HER2/neu

% density

41.7

39.8

0.71

30.4

33.5

0.51

 

Dense area

30.3

28.6

0.65

35.2

37.6

0.71

 

Number

55

24

 

49

28

 

Ki-67

% density

38.2

42.6

0.35

29.7

30.9

0.81

 

Dense area

25.4

31.8

0.07

35.8

34.5

0.85

 

Number

30

49

 

35

41

 

PCNA

% density

41.0

39.9

0.81

29.9

33.9

0.43

 

Dense area

29.4

28.8

0.86

33.7

40.5

0.32

 

Number

43

38

 

52

25

 
  1. * Categories for ERα, ERβ, HER2/neu and PCNA; category 1 <10% staining, category 2 ≥ 10% staining. Categories for PR and Ki-67; category 1 = no staining, category 2 = any staining
  2. † Mean percent breast density
  3. # Mean dense area in cm2
  4. Mean values and p-values calculated using general linear models adjusted for age at mammogram, BMI, ethnicity, HT use at mammogram, menopausal status, parity, age at first live birth, age at menarche and family history of breast cancer.
  5. (ERα = estrogen receptor alpha; ERβ = estrogen receptor beta; PR = progesterone receptor; HER2/neu = Human Epidermal growth factor receptor2; PCNA = Proliferating Cell Nuclear Antigen; BMI = body mass index)
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us