Variations in the NBN/NBS1 gene and the risk of breast cancer in non-BRCA1/2French Canadian families with high risk of breast cancer

Table 4 Estimated haplotypes using the WHAP program and all variants identified, for cases and controls combined.

		Estimated Haplotype Frequencies
Haplotype	SNPs¹ 10-1-2-3-4-5-6-11-12-13-7-14-15-16-17-18-19-8-20-9-21-22-23-24	Cases	Controls	Combined	p-value²
1	TGGTAGCTCGCGGGCCCTAAATCA	0.481	0.486	0.483	0.92
2	TAGTACCTCGCGGATAACGGTTCA	0.232	0.255	0.244	0.636
3	TGGTAGCCCGCGGGCCCTAAATCA	0.065	0.097	0.078	0.29
4	AGGTAGCTCGCGGGCCCTAAATCA	0.089	0.030	0.052	0.0205
5	TAGTAGCTCGCGGATAACGGTTCA	0.036	0.007	0.022	0.147
6	TGGTAGCTCGCGCGCCCTAAATCA	0.012	0.036	0.021	0.146
7	TAGTACCTCGCGGATAACGGTTGA	0.006	0.037	0.019	0.0403
8	TGGTAGCTCGCGGGCCCTAAATCG	0.019	0.022	0.015	0.846
9	TGGTAGCTCACAGGCCCCAAATCA	0.013	0.000	0.011	0.11
10	TGGTACCTCGCGGGCCCTAAATCA	0.012	0.008	0.010	0.749
11	TGGTAGCTTGCGGGCCCTAAATCA	0.006	0.014	0.008	0.47
12	TGGTAGCTCGCGGACCCTAAATCA	0.006	0.007	0.006	0.897
13	TGGTAGCTTGCGGGCCCTAAATCG	0.011	0.000	0.006	0.126
14	TGGTAGCTCACAGGCCCCAAATCG	0.011	0.008	0.006	0.128

¹SNPs identification as in Table 2 and 3. ² p-value for haplotype-specific test, each haplotype versus all other haplotypes.

ISSN: 1471-2407