Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study

BMC Cancer

Table 2 Associations between the seven SNPs in the FGFR2 and FGFR4 genes and skin cancer risk

SNP	Melanoma		SCC		BCC
	Additive OR*	p for trend	Additive OR*	p for trend	Additive OR*	p for trend
FGFR2 rs11200014	0.95 (0.77–1.19)	0.67	0.90 (0.74–1.10)	0.30	1.03 (0.85–1.26)	0.73
FGFR2 rs2981579	0.96 (0.77–1.19)	0.70	0.92 (0.75–1.12)	0.40	1.11 (0.91–1.36)	0.29
FGFR2 rs1219648	0.96 (0.77–1.20)	0.75	0.87 (0.71–1.07)	0.18	1.06 (0.87–1.29)	0.57
FGFR2 rs2420946	1.08 (0.85–1.38)	0.53	0.89 (0.72–1.10)	0.28	0.99 (0.81–1.21)	0.91
FGFR4 rs1966265**	1.16 (0.90–1.48)	0.26	1.00 (0.79–1.26)	1.00	0.94 (0.74–1.19)	0.61
FGFR4 rs376618	0.88 (0.67–1.14)	0.33	1.04 (0.83–1.31)	0.73	0.87 (0.69–1.11)	0.27
FGFR4 rs351855	1.09 (0.87–1.38)	0.44	0.90 (0.73–1.12)	0.35	1.13 (0.93–1.39)	0.21

*Unconditional logistic regression adjusted for age.
**The SNP rs1966265 failed the assay and the rs12519145 was genotyped instead (r² = 0.8).

ISSN: 1471-2407