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Table 3 Putative target genes for tumorigenesis and tumor progression in recurrent copy number changes of the 16 ESFT patients included in the integration analysis.

From: Combined use of expression and CGH arrays pinpoints novel candidate genes in Ewing sarcoma family of tumors

Symbol Name Cytoband Location1 Correlation p-value Copy number status2 q-value Functional information
HEATR3 HEAT repeat containing 3 16q12.1 48697286–48697733 0,876 2,2E-16 Deleted 6,05E-13 NA
TRAFD1 TRAF-type zinc finger domain containing 1 12q24.12 111075038–111075556 0,853 2,2E-16 Gained 6,05E-13 [47]
C1orf131 Chromosome 1 open reading frame 131 1q42.2 229426179–229426672 0,850 2,2E-16 Unspecified 6,05E-13 NA
HDGF Hepatoma-derived growth factor 1q21-q23 154978607–154979115 0,844 1,5E-05 Gained 0,024182394 [34, 3638]
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 12p13.1 12873623– 12874134 0,844 1,5E-05 Gained 0,024182394 [48]
GIGYF2 GRB10 interacting GYF protein 2 2q37.1 233431003–233431539 0,838 3,5E-05 Unspecified 0,047741159 [4951]
C2orf49 Chromosome 2 open reading frame 49 2q12.2 105331075–105331416 0,832 5,9E-05 Unspecified 0,069391132 NA
TMEM63A Transmembrane protein 63A 1q42.12 224110806–224111244 0,829 7,3E-05 Gained 0,07491325 NA
WDR67 WD repeat domain 67 8q24.13 124233227–124233523 0,826 8,8E-05 Gained 0,080319015 NA
GSDMD1 Gasdermin D 8q24.3 144710202–144710602 -0,821 1,3E-04 Gained 0,107927089 NA
GPATCH2 G patch domain containing 2 1q41 215848737–215849264 0,812 1,8E-04 Unspecified 0,137376561 NA
WSB2 WD repeat and SOCS box-containing 2 12q24.23 116955326–116955682 0,809 2,1E-04 Unspecified 0,142275217 [42]
CACNA1C Calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 2670999–2671234 -0,803 2,7E-04 Deleted 0,160672631 [40, 41]
KRT79 Keratin 79 12q13.13 51501640–51502010 -0,800 3,0E-04 Unspecified 0,160672631 NA
PPHLN1 Periphilin 1 12q12 41121456–41121979 0,797 3,2E-04 Gained 0,160672631 [43, 44]
C1orf107 Chromosome 1 open reading frame 107 1q32.2 208096981–208097464 0,794 3,5E-04 Gained 0,160672631 NA
FBXL14 F-box and leucine-rich repeat protein 14 12p13.33 1570852–1571348 0,794 3,5E-04 Unspecified 0,160672631 NA
ANKRD11 Ankyrin repeat domain 11 16q24.3 87999533–87999771 0,794 3,5E-04 Deleted 0,160672631 [45, 52]
HEATR1 HEAT repeat containing 1 1q43 234815741–234816376 0,791 3,9E-04 Gained 0,160672631 NA
COG2 Component of oligomeric golgi complex 2 1q42.2 228895774–228896323 0,791 3,9E-04 Gained 0,160672631 [39]
  1. 1Location of the Affymetrix target sequence using BLAST algorithm. 2Copy number status = characterization of the copy number status in the whole patient set; unspecified indicates that both amplifications and deletions were found. NA = not available.