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Table 4 Proteins chosen by BMA of linear models

From: Do serum biomarkers really measure breast cancer?

Protein Biological Role Higher Prevalence In
Normal vs. Cancer   
MIF (macrophage migration inhibitory factor) Inflammation, regulates macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids [6466] Cancer
MMP-9 (matrix metalloproteinase) Breakdown and remodeling of extracellular matrix [67], regulates growth plate angiogenesis and apoptosis of hypertrophic chondrocytes [68] Cancer
MPO (myeloperoxidase) Inflammation, produces HOCl, modulates vascular signaling and vasodilatory functions of nitric oxide (NO) during acute inflammation [69] Normal
sVCAM-1 (soluble vascular cell adhesion molecule 1) Mediates leukocyte-endothelial cell adhesion and signal transduction, membrane-bound adhesion molecules and the process of vascular inflammation of the vessel wall [70] Normal
ACTH (adrenocorticotropic hormone) Stimulates secretion of adrenal corticosteroids [71] Cancer
Normal vs. Benign   
MIF (macrophage migration inhibitory factor) Inflammation, regulates macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids [6466] Benign
MICA (MHC class I polypeptide-related sequence A) Stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells, ligands for natural killer cells [72] Benign
IL-5 (Interleukin 5) Stimulates B cell growth, increases immunoglobulin secretion, mediates eosinophil activation [73] Normal
IL-12 p40 (Interleukin 12, p40 chain) Differentiation of naive T cells into Th1 cells, stimulates the growth and function of T cells, stimulates the production of interferon-gamma (IFN-γ) and [74, 75](TNF-α) from T and natural killer cells, and reduces IL-4 mediated suppression of IFN-γ [76] Normal
MCP-1 (Monocyte chemotactic protein-1) Induces recruitment of monocytes, T lymphocytes, eosinophils, and basophils and is responsible for many inflammatory reactions to disease [77] Benign
Benign vs. Cancer   
CA-125 (cancer antigen 125) Marker for ovarian cancer [12, 81, 82] Cancer
IFNa (Interferon type I) Secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses [78] or interferon inducers; implicated in autoimmune diseases [79, 80] Benign
MICA (MHC class I polypeptide-related sequence A) Stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells, ligands for natural killer cells [72] Benign