Hyaluronidase activity and HYAL1–2 expression in human ovary and its tumors. A) Hyaluronidase activity in NO (n = 4), SCA (n = 8), BL (n = 3), G1–2 (n = 8) and G3 (n = 9) tissues. Relative mRNA levels of B) HYAL1 and C) HYAL2 in NO (n = 5), SCA (n = 10), BL (n = 4), G1–2 (n = 10) and G3 (n = 10). The boxes show the ranges between 25th and 75th percentiles, with a horizontal line at the median value. The whiskers extend to the 10th and 90th percentiles. The open circles represent the statistical outlier values. NO = normal ovary, SCA = serous cystadenoma, BL = serous borderline tumor, G1–2 = grade 1–2 serous cystadenocarcinoma, G3 = grade 3 serous cystadenocarcinoma.