Table 2 α1(IV), α4(IV), α6(IV) and α1(VII) mRNA levels in normal and neoplastic colonic tissues.
From: Collagen mRNA levels changes during colorectal cancer carcinogenesis
mRNA level in normal tissue* Mean (SD) | pa | mRNA level in neoplastic tissue Mean (SD) | pa | pb | |
|---|---|---|---|---|---|
α1(IV) | |||||
Healthy individual | 8.3 × 10-3 (6.5 × 10-3) | ||||
Patients with adenoma | 6.3 × 10-3 (2.6 × 10-3) | NS | 20.6 × 10-3 (10.4 × 10-3) | NS | < 0.001 |
Patients with carcinoma | 15.0 × 10-3 (14.6 × 10-3)** | NS | 53.6 × 10-3 (42.0 × 10-3) | < 0.001 | < 0.001 |
Patients with carcinoma | 20.2 × 10-3 (17.8 × 10-3)*** | NS | 53.6 × 10-3 (42.0 × 10-3) | < 0.001 | |
α4(IV) | |||||
Healthy individual | 8.8 × 10-5 (3.6 × 10-5) | ||||
Patients with adenoma | 8.6 × 10-5 (3.7 × 10-5) | NS | 4.4 × 10-5 (3.5 × 10-5) | NS | < 0.001 |
Patients with carcinoma | 17.5 × 10-5(18.7 × 10-5)** | NS | 11.4 × 10-5 (15.9 × 10-5) | NS | NS |
Patients with carcinoma | 20.1 × 10-5 (16.9 × 10-5)*** | NS | 11.4 × 10-5 (15.9 × 10-5) | < 0.01 | |
α6(IV) | |||||
Healthy individual | 8.2 × 10-5 (4.6 × 10-5) | ||||
Patients with adenoma | 9.4 × 10-5 (5.6 × 10-5) | NS | 9.3 × 10-5 (6.3 × 10-5) | NS | NS |
Patients with carcinoma | 7.1 × 10-5 (9.5 × 10-5)** | NS | 1.5 × 10-5 (2.8 × 10-5) | < 0.05 | < 0.001 |
Patients with carcinoma | 7.4 × 10-5 (9.8 × 10-5)*** | NS | 1.5 × 10-5 (2.8 × 10-5) | < 0.001 | |
α1(VII) | |||||
Healthy individual | 5.1 × 10-6 (1.8 × 10-6) | ||||
Patients with adenoma | 5.2 × 10-6 (3.8 × 10-6) | NS | 9.6 × 10-6 (6.0 × 10-6) | NS | < 0.01 |
Patients with carcinoma | 7.3 × 10-6 (7.6 × 10-6)** | NS | 17.8 × 10-6 (1.9 × 10-6) | < 0.01 | < 0.001 |
Patients with carcinoma | 7.3 × 10-6 (8.0 × 10-6)*** | NS | 17.8 × 10-6 (1.9 × 10-6) | < 0.001 |