Skip to main content

Table 2 Association between energy-adjusted nutrient intake and breast cancer risk in Brazilian women

From: Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women

  

Total

Premenopausal women

Postmenopausal women

Nutrient intake*

Tertile

Case/Control

OR†

(95% CI)†

Case/Control

OR‡

(95% CI)‡

Case/Control

OR‡

(95% CI)‡

Folate (ÎĽg/day)

<446.2

140/152

1.00

-

43/60

1.00

-

97/92

1.00

-

 

446.2-<602.2

42/153

1.05

(0.75–1.46)

58/50

1.73

(0.97–3.08)

84/103

0.77

(0.50–1.19)

 

≥ 602.2

176/153

1.26

(0.89–1.78)

83/59

2.17

(1.23–3.83)

93/94

0.91

(0.59–1.41)

 

P trend

 

0.217

  

0.010

  

0.685

 

Vitamin B6 (mg/day)

<0.6

145/152

1.00

-

63/49

1.00

-

82/103

1.00

-

 

0.6–<1.0

148/153

1.04

(0.74–1.46)

57/54

0.80

(0.46–1.39)

91/99

1.30

(0.85–1.98)

 

≥ 1.0

165/153

1.18

(0.84–1.65)

64/66

0.81

(0.48–1.37)

101/87

1.54

(1.01–2.35)

 

P trend

 

0.384

  

0.418

  

0.047

 

Vitamin B12 (ÎĽg/day)

<3.9

165/152

1.00

-

61/49

1.00

-

104/103

1.00

-

 

3.9–<7.3

143/153

0.90

(0.64–1.25)

55/56

0.77

(0.45–1.33)

88/97

0.96

(0.64–1.45)

 

≥ 7.3

150/153

0.90

(0.65–1.26)

68/64

0.83

(0.49–1.41)

82/89

1.00

(0.65–1.52)

 

P trend

 

0.531

  

0.486

  

0.949

 
  1. *Energy-adjusted intakes were categorized among controls by tertiles of folate, vitamin B6, and vitamin B12 for total Brazilian women.
  2. †Adjusted for smoking status (never/ever), alcohol consumption (never/ever), moderate physical activity in the preceding 5 years (no/yes), and number of live births (nulliparous/1–2/≥3).
  3. ‡Adjusted for age group (20-/30-/40-/50-/60-/≥70), ethnicity (white/mixed/black/yellow), smoking status (never/ever), alcohol consumption (never/ever), moderate physical activity in the preceding 5 years (no/yes), and number of live births (nulliparous/1–2/≥3).