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Table 2 Hazard ratios for cancer specific and all cause mortality for patients with specified co-morbidities

From: The effect of comorbidity on the use of adjuvant chemotherapy and survival from colon cancer: a retrospective cohort study

  Crude HR   Adjusted for pt factors1   Adjusted for pt and disease factors2  
Cancer specific mortality
Angina 0.74 0.48–1.15 0.75 0.48–1.19 0.81 0.51–1.30
Hypertension 0.97 0.74–1.27 0.96 0.72–1.28 0.92 0.69–1.23
Previous MI 1.23 0.77–1.97 1.30 0.81–2.11 1.49 0.90–2.46
Cardiac arrhythmias 0.82 0.54–1.25 0.88 0.57–1.36 1.17 0.74–1.83
CHF 1.13 0.74–1.75 1.10 0.70–1.72 1.83 1.14–2.93
PVD 0.64 0.26–1.55 0.71 0.39–1.75 1.18 0.48–2.93
Chronic respiratory disease 1.16 0.85–1.58 1.06 0.77–1.46 1.24 0.89–1.74
GI ulcer disease 0.49 0.20–1.18 0.50 0.21–1.22 0.76 0.31–1.87
Other cancer 0.77 0.36–1.63 0.79 0.37–1.71 0.71 0.32–1.55
Cerebrovasc disease 1.23 0.75–2.02 1.30 0.78–2.16 1.25 0.74–2.10
Diabetes (all) 1.18 0.84–1.68 1.14 0.79–1.63 1.27 0.88–1.84
Renal disease (all) 1.10 0.60–2.01 1.01 0.54–1.87 1.42 0.76–2.66
Other neurological 1.19 0.71–1.97 1.35 0.80–2.25 1.96 1.12–3.42
Charlson comorbidity index       
   O 1.00   1.00   1.00  
   1–2 1.26 0.96–1.66 1.22 0.91–1.64 1.32 0.98–1.77
   3+ 0.86 0.52–1.42 0.88 0.53–1.47 1.48 0.88–2.50
Number of conditions*       
   0 1.00   1.00   1.00  
   1 1.30 0.93–1.80 1.29 0.92–1.83 1.06 0.76–1.55
   2 1.15 0.79–1.68 1.13 0.75–1.70 1.23 0.81–1.87
   3+ 1.00 0.69–1.45 1.01 0.67–1.53 1.33 0.87–2.04
All-cause mortality
Angina 0.96 0.68–1.34 0.86 0.61–1.23 0.91 0.63–1.31
Hypertension 1.03 0.82–1.29 0.93 0.73–1.19 0.90 0.70–1.15
Previous MI 1.67 1.17–2.38 1.74 1.21–2.52 1.91 1.31–2.79
Cardiac arrhythmias 1.26 0.93–1.72 1.19 0.86–1.65 1.48 1.07–2.06
CHF 1.79 1.31–2.45 1.61 1.16–2.24 2.30 1.63–3.25
PVD 1.46 0.87–2.46 1.40 0.82–2.40 2.02 1.18–3.48
Chronic respiratory disease 1.29 0.99–1.66 1.12 0.85–1.46 1.26 0.96–1.66
GI ulcer disease 0.61 0.32–1.19 0.60 0.31–1.17 0.76 0.38–1.49
Other cancer 1.31 0.79–2.16 1.25 0.74–2.10 1.16 0.68–1.98
Cerebrovasc disease 1.36 0.91–2.04 1.28 0.85–1.93 1.27 0.84–1.94
Diabetes (all) 1.48 1.12–1.95 1.44 1.08–1.92 1.53 1.15–2.05
Renal disease (all) 1.52 0.96–2.39 1.32 0.83–2.10 1.79 1.12–2.86
Other neurological 1.44 0.97–2.16 1.58 1.05–2.38 2.02 1.32–3.11
CCI       
   O 1.00   1.00   1.00  
   1–2 1.68 1.32–2.14 1.55 1.20–2.00 1.60 1.24–2.07
   3+ 1.84 1.30–2.60 1.78 1.24–2.55 2.63 1.82–3.81
Number of conditions*       
   0 1.00   1.00   1.00  
   1 1.30 0.95–1.78 1.26 0.92–1.73 1.08 0.78–1.49
   2 1.50 1.08–2.08 1.40 0.98–1.99 1.45 1.01–2.07
   3+ 1.73 1.28–2.35 1.63 1.17–2.28 2.00 1.41–2.82
  1. 1 includes age, sex, ethnicity, NZdep, year of registration, smoking
  2. 2 includes age, sex, ethnicity, NZdep, year of registration, smoking, stage, grade and site of cancer
  3. * Included all conditions included in Charlson Comorbidity Index as well as angina, hypertension, cardiac arrhythmias, previous pulmonary embolism, cardiac valve disease, inflammatory bowel disease, other neurological conditions (including multiple sclerosis, Parkinson's disease, epilepsy) and major psychiatric conditions (including schizophrenia, bipolar disease and depressive psychosis)