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Table 7 Association of genotypes for the PON1 Q192R and PON1 L55M SNPs and breast cancer

From: CYP17, GSTP1, PON1 and GLO1gene polymorphisms as risk factors for breast cancer: an Italian case-control study

  QQ QR RR QR and RR
PON1 Q192R     
All     
Cases, n (%) 484 (88.5) 50 (9.1) 13 (2.4) 63 (11.5)
Controls, n (%) 340 (62.5) 152 (28.0) 52 (9.5) 204 (37.5)
OR (95% CI)a 1.0 0.58 (0.32–0.99) 0.45 (0.18–0.88)b 0.55 (0.30–0.95)
Menopausal status at diagnosis     
   Premenopausal     
Cases, n (%) 135 (72.2) 41 (21.9) 11 (5.9) 52 (27.8)
Controls, n (%) 144 (62.6) 64 (27.8) 22 (9.6) 86 (37.4)
OR (95% CI) a 1.0 0.73 (0.51–1.43) 0.64 (0.40–1.44)b 0.68 (0.47–1.47)
   Postmenopausal     
Cases, n (%) 349 (96.9) 9 (2.5) 2 (0.6) 11 (3.1)
Controls, n (%) 196 (62.4) 88 (28.0) 30 (9.6) 118 (37.6)
OR (95% CI) a 1.0 0.12 (0.01–0.33) 0.08 (0.01–0.14)b 0.05 (0.02–0.12)
PON1 L55M LL LM MM LM and MM
All     
Cases, n (%) 107 (19.6) 115 (21.0) 325 (59.4) 440 (80.4)
Controls, n (%) 188 (34.6) 125 (23.0) 231 (42.4) 356 (65.4)
OR (95% CI)a 1.0 1.80 (1.36–2.56) 2.81 (1.95–3.64)c 2.42 (1.73–2.99)
Menopausal status at diagnosis     
   Premenopausal     
Cases, n (%) 30 (16.1) 33 (17.6) 124 (66.3) 157 (83.9)
Controls, n (%) 78 (33.9) 70 (30.4) 82 (35.7) 152 (66.1)
OR (95% CI) a 1.0 1.26 (0.66–2.39) 3.83 (2.15–5.87)c 2.67 (1.62–4.15)
   Postmenopausal     
Cases, n (%) 77 (21.4) 82 (22.8) 201(55.8) 283 (78.6)
Controls, n (%) 110 (35.0) 55 (17.5) 149 (47.5) 204 (65.0)
OR (95% CI) a 1.0 2.23 (1.39–3.40) 2.06 (1.30–2.97)c 2.59 (1.35–3.06)
  1. aAdjusted for age, age at menarche, age at FFTP, number of full term pregnancies, first-degree family history of breast cancer, history of benign breast disease, use of oral contraceptives, WHR, alcohol consumption, smoking habits, level of education and postmenopausal use of estrogen. bP for trend: all, 0.01; premenopausal, 0.29; postmenopausal, 0.001. cP for trend: all, premenopausal, postmenopausal, 0.001.