CYP17, GSTP1, PON1 and GLO1gene polymorphisms as risk factors for breast cancer: an Italian case-control study

Table 7 Association of genotypes for the PON1 Q192R and PON1 L55M SNPs and breast cancer

	QQ	QR	RR	QR and RR
PON1 Q192R
All
Cases, n (%)	484 (88.5)	50 (9.1)	13 (2.4)	63 (11.5)
Controls, n (%)	340 (62.5)	152 (28.0)	52 (9.5)	204 (37.5)
OR (95% CI)^a	1.0	0.58 (0.32–0.99)	0.45 (0.18–0.88)^b	0.55 (0.30–0.95)
Menopausal status at diagnosis
Premenopausal
Cases, n (%)	135 (72.2)	41 (21.9)	11 (5.9)	52 (27.8)
Controls, n (%)	144 (62.6)	64 (27.8)	22 (9.6)	86 (37.4)
OR (95% CI) ^a	1.0	0.73 (0.51–1.43)	0.64 (0.40–1.44)^b	0.68 (0.47–1.47)
Postmenopausal
Cases, n (%)	349 (96.9)	9 (2.5)	2 (0.6)	11 (3.1)
Controls, n (%)	196 (62.4)	88 (28.0)	30 (9.6)	118 (37.6)
OR (95% CI) ^a	1.0	0.12 (0.01–0.33)	0.08 (0.01–0.14)^b	0.05 (0.02–0.12)
PON1 L55M	LL	LM	MM	LM and MM
All
Cases, n (%)	107 (19.6)	115 (21.0)	325 (59.4)	440 (80.4)
Controls, n (%)	188 (34.6)	125 (23.0)	231 (42.4)	356 (65.4)
OR (95% CI)^a	1.0	1.80 (1.36–2.56)	2.81 (1.95–3.64)^c	2.42 (1.73–2.99)
Menopausal status at diagnosis
Premenopausal
Cases, n (%)	30 (16.1)	33 (17.6)	124 (66.3)	157 (83.9)
Controls, n (%)	78 (33.9)	70 (30.4)	82 (35.7)	152 (66.1)
OR (95% CI) ^a	1.0	1.26 (0.66–2.39)	3.83 (2.15–5.87)^c	2.67 (1.62–4.15)
Postmenopausal
Cases, n (%)	77 (21.4)	82 (22.8)	201(55.8)	283 (78.6)
Controls, n (%)	110 (35.0)	55 (17.5)	149 (47.5)	204 (65.0)
OR (95% CI) ^a	1.0	2.23 (1.39–3.40)	2.06 (1.30–2.97)^c	2.59 (1.35–3.06)

^aAdjusted for age, age at menarche, age at FFTP, number of full term pregnancies, first-degree family history of breast cancer, history of benign breast disease, use of oral contraceptives, WHR, alcohol consumption, smoking habits, level of education and postmenopausal use of estrogen. ^bP for trend: all, 0.01; premenopausal, 0.29; postmenopausal, 0.001. ^cP for trend: all, premenopausal, postmenopausal, 0.001.

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